N-Desmethyltamoxifen hydrochloride |
| Catalog No.GC38931 |
N-Desmethyltamoxifen 염산염은 인간에서 tamoxifen의 주요 대사 산물입니다. 열악한 항에스트로겐인 N-데스메틸타목시펜은 타목시펜보다 10배 더 강력한 단백질 키나제 C(PKC) 억제제입니다. N-Desmethyltamoxifen 염산염은 또한 인간 AML 세포에서 세라마이드 대사의 강력한 조절자로서 세라마이드 글리코실화, 가수분해 및 스핑고신 인산화를 제한합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 15917-65-4
Sample solution is provided at 25 µL, 10mM.
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N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation[1][2][3].
N-desmethyltamoxifen hydrochloride (20-500 ng/ml; 48 hours) has a profound inhibitory effect upon all seven glioma lines (T98G, U87, U138, U373, ALW, AUK, CAS cells)[1].N-desmethyltamoxifen hydrochloride (1.5-10 μM; 114 hours) inhibits growth of MCF 7 human mammary carcinoma cells[2].N-desmethyltamoxifen hydrochloride, resulting from the CYP3A4/5-mediated catalysis of tamoxifen, is the major primary quantitative metabolite of tamoxifen[3]. Cell Viability Assay[2] Cell Line: MCF 7 human mammary carcinoma cells
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