NMS-859 |
| カタログ番号GC32874 |
NMS-859 は強力な共有結合 VCP (p97) 阻害剤であり、細胞内に 60 μM および 1 mM ATP が存在する場合、野生型 VCP の IC50 はそれぞれ 0.37 および 0.36 μM です。
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Cas No.: 1449236-96-7
Sample solution is provided at 25 µL, 10mM.
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NMS-859 is a potent, covalent VCP (p97) inhibitor, with IC50s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.
NMS-859 is a potent VCP inhibitor, with IC50s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively. NMS-859 shows very weak inhibitory activity against VCPC522T. NMS-859 also suppresses the proliferation of cells, with IC50s of 3.5 μM and 3.0 μM in HCT116 and HeLa cell lines, respectively[1].
[1]. Magnaghi P, et al. Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013 Sep;9(9):548-56.
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