PROTAC RAR Degrader-1 |
| カタログ番号GC34740 |
PROTAC RAR Degrader-1 は、IAP リガンド結合基、リンカー、および RAR リガンド結合基を含みます。 PROTAC RAR Degrader-1 は、RAR デグレーダーです。 HT1080 細胞における 30 μM 濃度での最大 RAR 分解。 cIAP1 に基づく分解誘導物質は、特異的かつ非遺伝的な IAP 依存性タンパク質消去剤 (SNIPER) と呼ばれます。
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Cas No.: 1351169-27-1
Sample solution is provided at 25 µL, 10mM.
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PROTAC RAR Degrader-1 comprises a cIAP1 ligand binding group, a linker and a RAR ligand binding group. PROTAC RAR Degrader-1 is an RAR degrader. Maximal RAR degradation at 30 μM concentration in HT1080 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].
[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019 Jan 25;17:160-176.
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