Tyrosine kinase-IN-1 |
カタログ番号GC34026 |
チロシンキナーゼ-IN-1 は、KDR、Flt-1、FGFR1、および PDGFRα の IC50 がそれぞれ 4、20、4、2 nM の多標的チロシンキナーゼ阻害剤です。
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Cas No.: 705946-27-6
Sample solution is provided at 25 µL, 10mM.
Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor with IC50s of 4, 20, 4, 2 nM for KDR, Flt-1, FGFR1 and PDGFRα, respectively.
Tyrosine kinase-IN-1 is from reference (compound 8K)[1].
Tyrosine kinase-IN-1 shows a reasonable PK profile (AUC(0-∞)=1.9, t1/2=4.6 h). It has a favorable oral bioavailability (F=63%) in rats[1].
[1]. Moon K, et al. The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 22 (2012) 4979-4985
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