SB 332235 |
| カタログ番号GC50230 |
SB 332235 は、強力な経口活性非ペプチド CXCR2 アンタゴニストであり、IC50 は 7.7 nM です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 276702-15-9
Sample solution is provided at 25 µL, 10mM.
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Potent CXCR2 antagonist (IC50 = 7.7 nM). Exhibits 285-fold selectivity for CXCR2 over CXCR1. Reduces leukocyte numbers in synovial fluid in acute and chronic rabbit arthritis models. Also reduces synovial fluid eicosanoid and cytokine levels in a rabbit chronic arthritis model. Inhibits proliferation of AML cell lines in vitro.
Podolin et al (2002) A potent and selective nonpeptide antagonist of CXCR2 inhibits acute and chronic models of arthritis in the rabbit. J.Immunol. 169 6435 PMID:12444152 |Schinke et al (2015) IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells. Blood 125 3144 PMID:25810490
Average Rating: 5 (Based on Reviews and 10 reference(s) in Google Scholar.)
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