Tauroursodeoxycholate dihydrate |
| カタログ番号GC34831 |
Tauroursodeoxycholic 酸 (Tauroursodeoxycholic 酸; TDUCA) 二水和物は、小胞体 (ER) ストレス阻害剤です。タウロウルソデオキシコール酸は、カスパーゼ-3 やカスパーゼ-12 などのアポトーシス分子の発現を大幅に減少させます。 Tauroursodeoxycholate も ERK を阻害します。
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Cas No.: 117609-50-4
Sample solution is provided at 25 µL, 10mM.
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Tauroursodeoxycholate dihydrate (TUDCA dihydrate; UR 906 dihydrate; Taurolite dihydrate) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK[1][2]. ERK[1]Caspase-3, Caspase-12[2]
[1]. Kim SY, et al. Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK viaPKCα-mediated MKP-1 induction. Cardiovasc Res. 2011 Nov 1;92(2):307-16. [2]. Qin Y, et al. Tauroursodeoxycholic Acid Attenuates Angiotensin II Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice by Inhibiting Endoplasmic Reticulum Stress. Eur J Vasc Endovasc Surg. 2017 Mar;53(3):337-345.
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