Tetrachlorohydroquinone (Synonyms: NSC 4858, NSC 100888, TCHQ) |
| カタログ番号GC45020 |
テトラクロロヒドロキノン（TCHQ）は、有機塩素系殺菌剤ペンタクロロフェノールの代謝物です。
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Cas No.: 87-87-6
Sample solution is provided at 25 µL, 10mM.
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Tetrachlorohydroquinone (TCHQ) is a metabolite of the organochlorine biocide pentachlorophenol. It is cytotoxic to RTL-W1 rainbow trout liver cells (EC50 = 1.55 μM in a neutral red assay). TCHQ increases production of reactive oxygen species (ROS), inhibits apoptosis, and induces loss of the mitochondrial membrane potential and necrosis in splenocytes. In vivo, TCHQ induces glutathione (GSH) depletion in mouse liver.
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