TMPyP4 tosylate (Synonyms: TMP-1363, TMPyP4 4-methylbenzenesulfonate) |
カタログ番号GC12092 |
TMPyP4 トシレート (TMP 1363) は、四重鎖特異的リガンドであり、G-四重鎖と IGF-1 の間の相互作用を阻害します。 TMPyP4 トシレート (TMP 1363) は、骨肉腫細胞株で抗腫瘍効果を持つテロメラーゼ阻害剤です。
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Cas No.: 36951-72-1
Sample solution is provided at 25 µL, 10mM.
TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand, which inhibits the interaction between G-quadruplexes and IGF-1[1]. TMPyP4 tosylate (TMP 1363) is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines[2].
References:
[1]. Chen H, et al. Insuline-like growth factor type I selectively binds to G-quadruplex structures. Biochim Biophys Acta Gen Subj. 2019 Jan;1863(1):31-38.
[2]. Fujimori J, et al. Antitumor effects of telomerase inhibitor TMPyP4 in osteosarcoma cell lines. J Orthop Res. 2011 Nov;29(11):1707-11.
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