Trandolaprilat (hydrate) (Synonyms: RU 44403) |
| カタログ番号GC46233 |
トランドラプリラート（水和物）は、強力なアンギオテンシン変換酵素（ACE）阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 951393-55-8
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Trandolaprilat is an angiotensin-converting enzyme (ACE) inhibitor.[1] It inhibits angiotensin I-induced contraction in isolated rat thoracic aorta (IC50 = 6.9 nM) and potentiates bradykinin-induced contraction in isolated guinea pig ileum with a 50% augmentation concentration (AC50) value of 2.7 nM. Trandolaprilat induces relaxation of norepinephrine- or potassium chloride-precontracted isolated rat thoracic aorta with intact endothelium in a concentration-dependent manner. Trandolaprilat inhibits angiotensin I-induced pressor responses in rats and dogs (ID50s = 9.9 and 7.2 μg/kg, respectively) and potentiates the bradykinin-induced depressor response in rats (ED50 = 5.5 μg/kg).[2]
Reference:
[1]. Sekiguchi, N., Ishii, Y., Fujikura, H., et al. Pharmacological action of (-)-(2S,3aR,7aS)-1-[(S)-N-[(S)-1-carbonyl-3-phenylpropyl]alanyl]hexahydro-2-indolinecarboxylic acid (trandolaprilat) in isolated smooth muscle preparations. Gen. Pharmacol. 24(3), 585-590 (1993).
[2]. Brown, N.L., Badel, M.-Y., Benzoni, F., et al. Angiotensin-converting enzyme inhibition, anti-hypertensive activity and hemodynamic profile of trandolapril (RU 44570). Eur. J. Pharmacol. 148(1), 79-91 (1988).
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *