trans-EKODE-(E)-Ib (Synonyms: 12,13epoxy9keto10(trans)Octadecenoic Acid) |
| カタログ番号GC45071 |
酸化ストレス中、豊富な不飽和脂肪酸リノール酸は脂質過酸化反応を受けてα,β-不飽和エポキシケト-オクタデセン酸（EKODE）を生成します。
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Cas No.: 478931-82-7
Sample solution is provided at 25 µL, 10mM.
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During oxidative stress, the abundant unsaturated fatty acid linoleic acid undergoes lipid peroxidation to produce α,β-unsaturated epoxy-keto-octadecenoic acids (EKODEs). Nonenzymatic autooxidation of linoleic acid generates six major EKODE isomers, which differ from one another in the positioning and the orientation of the epoxy group relative to the keto moiety. trans-EKODE-(E)-Ib is a biologically active peroxidation product of linoleic acid that is characterized, structurally, by having a trans carbon-carbon double bond between the 9-keto and 12,13-epoxy groups. It activates an antioxidant response element (ARE) in neuronal cells and induces the expression of ARE-regulated cytoprotective genes like NQO1. This EKODE also stimulates the synthesis of aldosterone and corticosterone in adrenal cells when supplied at 1-5 μM. This effect appears to be mediated by a rise in intracellular calcium.
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