Ursocholic acid (Synonyms: 7β-Hydroisocholic Acid, 7-Epichoic Acid, 3α,7β,12α-Trihydroxy-5β-cholanoic Acid, UCA) |
| カタログ番号GC33799 |
哺乳類の胆汁に主に含まれる胆汁酸であるウルソコール酸は、マウスの腸内細菌叢によってデオキシコール酸に変換されます。
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Cas No.: 2955-27-3
Sample solution is provided at 25 µL, 10mM.
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Ursocholic acid, a bile acid found predominantly in bile of mammals, is an inhibitor of 7α-hydroxysteroid dehydrogenase and hepatocyte nuclear factor 1α.
[1]. MacDonald IA, et al. Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7 alpha-hydroxysteroid dehydrogenase-elaborating organisms. Appl Environ Microbiol. 1982 Nov;44(5):1187-95. [2]. Lee HI, et al. Ursodeoxycholic acid, an inhibitor of hepatocyte nuclear factor 1α, did not increase the systemic exposure of pitavastatin. Int J Clin Pharmacol Ther. 2014 Nov;52(11):981-5.
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