USP7/USP47 inhibitor |
| カタログ番号GC18160 |
USP7/USP47 阻害剤は、選択的ユビキチン特異的プロテアーゼ 7/47 (USP7/USP47) 阻害剤であり、EC50 はそれぞれ 0.42 μM および 1.0 μM です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1247825-37-1
Sample solution is provided at 25 µL, 10mM.
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USP7/USP47 inhibitor(compound 14) is a selective USP7 (EC50= 0.42 μM)/USP47 (EC50= 1.0 μM) inhibitor but does not inhibit caspase 3, calpain 1, 20S proteasome, and a panel of representative USPs (USP2, USP5, USP8, USP21, and USP28; EC50 > 31.6 μM Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47. compound 14 exhibits enhanced potency against HCT-116 cells. treatment of cells with compound 14 resulted in an increase in p53 and an appreciable induction of p21 protein over the DMSO control. Thus, compound 14 penetrated the cells and modulated p53 and p21 as expected for a USP7 inhibitor.
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)
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