YF-2 |
Katalog-Nr.GC31099 |
YF-2 ist ein hochselektiver, fÜr die Blut-Hirn-Schranke durchlÄssiger Histon-Acetyltransferase-Aktivator, der H3 im Hippocampus acetyliert, mit EC50-Werten von 2,75 μM, 29,04 μM und 49,31 μM fÜr CBP, PCAF bzw. GCN5, zeigt keine Wirkung auf HDAC .
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Cas No.: 1311423-89-8
Sample solution is provided at 25 µL, 10mM.
YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease[1].
YF-2 (0.03, 0.1, 0.25, 0.5, 1, 2.5, 5, 15, 40 and 80 μM, 72 hours) inhibits the preliferation of U251, CCRF-CEM, Hs578T, NCI-ADR-RES cells[1].
YF-2 (20 mg/kg, 2 hours befor electric shock or 5 mg/kg, 30 min before the electric shock, i.p.) rescues the defect in contextual memory in mice, and shows no effect on contextual memory alone at 20 mg/kg in mice[1].
[1]. FENG, Yen, et al. HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF. WO 2011072243A1.
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