(-)-Zuonin A |
| カタログ番号GC60393 |
(-)-ズオニン A (D-エピガルバシン) は、天然に存在するリグニンであり、JNK1、JNK2、および JNK3 に対してそれぞれ 1.7 μM、2.9 μM、および 1.74 μM の IC50 を持つ強力な選択的 JNK 阻害剤です。
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Cas No.: 84709-25-1
Sample solution is provided at 25 µL, 10mM.
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(-)-Zuonin A (D-Epigalbacin), a naturally occurring lignin, is a potent, selective JNKs inhibitor, with IC50s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively[1].
(-)-zuonin A binds the D-recruitment site (DRS) of JNK, a recruitment site utilized by substrates and other substrates to dock onto and recognize MAPKs[1].(-)-zuonin A inhibits JNK activation by MKK4 and MKK7 and it inhibits substrate phosphorylation[1].
[1]. Tamer S. Kaoud, et al. Manipulating JNK Signaling with (-)-zuonin A. ACS Chem Biol. 2012 Nov 16; 7(11): 1873-1883.
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