ACY-1083 |
| Catalog No.GC34458 |
ACY-1083는 선택적이고 뇌 침투성 HDAC6 억제제로, IC50 값은 3nM이며 다른 모든 클래스의 HDAC 아이소폼보다 HDAC6에 대해 260배 더 선택적입니다. ACY-1083은 화학요법 유발 말초 신경병증을 효과적으로 개선시킵니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1708113-43-2
Sample solution is provided at 25 µL, 10mM.
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ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy[1]. HDAC6|3 nM (IC50)
[1]. Krukowski K, et al. HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy. Pain. 2017 Jun;158(6):1126-1137.
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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