Antennapedia Peptide |
| Catalog No.GC33336 |
Antennapedia Peptide는 원래 Drosophila 전사 인자 Antennapedia의 60개 아미노산 길이 호메오도메인에서 파생된 16개 아미노산 펩타이드이며 세포 투과성 펩타이드 계열의 구성원입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 188842-14-0
Sample solution is provided at 25 µL, 10mM.
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Antennapedia Peptide is a 16 amino acid peptide, originally derived from the 60 amino acid long homeodomain of the Drosophila transcription factor Antennapedia and is a member of the family of Cell-penetrating peptides.
Antennapedia (Antp)-SMCC-cytochrome c conjugate (5 μg/mL) activates caspase-dependent apoptosis of HeLa cells. The Antp-SMCC-cytochrome c conjugate reduces the clonogenic survival of Hela cells, and inhibits clonogenic survival[1]. ANTP-SmacN7 fusion protein can transduce and accumulate in cells, while SmacN7 alone cannot. ANTP-SmacN7 fusion proteins have a radiation-sensitising effect on EC109 cells. ANTP-SmacN7 combined with radiation does not promote further increases in caspase-3 protein expression, it increases the levels of cleaved caspase-3[2].
[1]. Imesch P, et al. Conjugates of cytochrome c and antennapedia peptide activate apoptosis and inhibit proliferation of HeLa cancer cells. Exp Ther Med. 2013 Sep;6(3):786-790. Epub 2013 Jul 4. [2]. Du LQ, et al. Radiation-sensitising effects of antennapedia proteins (ANTP)-SmacN7 on tumour cells. Int J Mol Sci. 2013 Dec 11;14(12):24087-96.
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