Argipressin (Vasopressin) |
| Catalog No.GC30764 |
Argipressin (Vasopressin) (Arg8-vasopressin)은 V1, V2, V3-vascular arginine vasopressin receptor에 결합하며, A7r5 쥐 대동맥 매끄러운 근육 세포에서 V1의 Kd 값은 1.31 nM입니다.
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Cas No.: 113-79-1
Sample solution is provided at 25 µL, 10mM.
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Arginine-vasopressin, as an important hormone in the regulation of plasma osmolality and blood volume/pressure, always is used in the treatment of septic shock and decompensated cirrhosis.[1]
In vitro experiment it shown that treatment with 5-10 µM argipressin (vasopressin) in RN46A cells decreased RN46A proliferation, while 10 µM argipressin (vasopressin) decreased the number of cells extending neurites. [2] In vitro, treatment with 0.1 µM and 1 µM. argipressin (vasopressin)in PV cardiomyocytes, there had a faster dose dependent beating rate than control PV cardiomyocytes by 4 and 37% respectively. [3] In vitro, Arginine vasopressin (10-12M-10-6M) can induce markedly concentration-dependent increases of insulin release from both rodent and human beta-cells, as well as mouse islets.[4] Moreover, treatment with 100 pM to 1 µM Arginine-vasopressin in the non-neuronal cells evoked [Ca2+](i) responses and had concentration-dependent responses increased with days in vitro in culture, reaching a maximum amplitude after 4-5 day. [5]
In vivo efficacy test it exhibited that argipressin (vasopressin) shown antinociception in the hot-plate test after intracerebroventricular injection (0.5 ug) and in the acetic acid abdominal constriction test after intraperitoneal injection (0.1 mg/kg).[6] In vivo experiment it demonstrated that treatment with 0.5 u/kg arginine vasopressin intravenously significantly increased the levels of IL-6 mRNA in rat hearts with the maximum level occurred at 6 h.[7]
References:
[1] Wagener G, Bakker J. Vasopressin in cirrhosis and sepsis: physiology and clinical implications. Minerva Anestesiol. 2015 Dec;81(12):1377-83. Epub 2014 Nov 11.
[2] Marinova Z, et al. Effects of oxytocin and Argipressin (Vasopressin) on the proliferation and differentiation of a serotonergic cell line. J Neural Transm (Vienna). 2018 Jan;125(1):103-106.
[3] Huang JH, et al. Argipressin (Vasopressin) modulates electrical activity and calcium homeostasis in pulmonary vein cardiomyocytes. J Biomed Sci. 2019 Sep 17;26(1):71.
[4] Mohan S, et al. Vasopressin receptors in islets enhance glucose tolerance, pancreatic beta-cell secretory function, proliferation and survival. Biochimie. 2019 Mar;158:191-198.
[5] Moriya T, et al. Vasopressin-induced intracellular Ca²⁺ concentration responses in non-neuronal cells of the rat dorsal root ganglion. Brain Res. 2012 Nov 5;1483:1-12.
[6] Hart SL, Oluyomi AO. Vasopressin and stress-induced antinociception in the mouse. Br J Pharmacol. 1990 Feb;99(2):243-6.
[7] Sun SZ, et al. β-Arrestin 2 mediates Argipressin (Vasopressin)-induced IL-6 induction via the ERK1/2-NF-κB signal pathway in murine hearts. Acta Pharmacol Sin. 2020 Feb;41(2):198-207.
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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