3'-Hydroxypterostilbene |
| Catalog No.GC35112 |
3'-Hydroxypterostilbene은 Pterostilbene 유사체입니다. 3'-Hydroxypterostilbene은 각각 9.0, 40.2 및 70.9μM의 IC50으로 COLO 205, HCT-116 및 HT-29 세포의 성장을 억제합니다. 3'-Hydroxypterostilbene은 PI3K/Akt 및 MAPK 신호 전달 경로를 유의하게 하향 조절하고 세포자멸사 및 자가포식을 유도하여 인간 결장암 세포의 성장을 효과적으로 억제합니다. 3'-Hydroxypterostilbene은 암 연구에 사용할 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 475231-21-1
Sample solution is provided at 25 µL, 10mM.
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3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 µM for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways[1]. Apoptosis[1]Autophagy[1]
[1]. Cheng TC, et al. Potent anti-cancer effect of 3'-hydroxypterostilbene in human colon xenograft tumors. PLoS One. 2014 Nov 12;9(11):e111814.
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