Nampt-IN-3 |
Catalog No.GC36690 |
Nampt-IN-3(화합물 35)은 각각 31nM 및 55nM의 IC50으로 니코틴아미드 포스포리보실트랜스퍼라제(NAMPT) 및 HDAC를 동시에 억제합니다. Nampt-IN-3는 세포 사멸과 자가포식을 효과적으로 유도하여 궁극적으로 세포 사멸을 유도합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2121591-52-2
Sample solution is provided at 25 µL, 10mM.
Nampt-IN-3 (Compound 35) simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC50s of 31 nM and 55 nM, respectively. Nampt-IN-3 effectively induces cell apoptosis and autophagy and ultimately leads to cell death[1].
[1]. Dong G, et al. Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors. J Med Chem. 2017 Oct 12;60(19):7965-7983.
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