L67 (Synonyms: DNA Ligase Inhibitor) |
Catalog No.GC18186
One-Click Copy Product Info
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L67(DNA Ligase Inhibitor)은 DNA 리가제 I/III(둘 다 IC50은 10μM임)를 효과적으로 억제하는 경쟁적 DNA 리가제 억제제입니다. L67(DNA Ligase Inhibitor)은 미토콘드리아 DNA 수준을 감소시키고 미토콘드리아 생성 ROS 수준을 증가시켜 핵 DNA 손상을 일으킬 수 있습니다. L67(DNA Ligase Inhibitor)은 또한 암세포에서 Caspase 1 의존성 세포자멸사 경로를 활성화하여 암 연구에 사용할 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 325970-71-6
Sample solution is provided at 25 µL, 10mM.
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| Cas No. | 325970-71-6 | SDF | |
| Synonyms | DNA Ligase Inhibitor | ||
| Chemical Name | N-(3,5-dibromo-4-methylphenyl)-glycine, 2-[(2-hydroxy-5-nitrophenyl)methylene]hydrazide | ||
| Canonical SMILES | OC1=CC=C([N+]([O-])=O)C=C1/C=N/NC(CNC2=CC(Br)=C(C)C(Br)=C2)=O | ||
| Formula | C16H14Br2N4O4 | M.Wt | 486.1 |
| Solubility | DMF: 10 mg/ml,DMSO: 10 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.0572 mL | 10.2859 mL | 20.5719 mL |
| 5 mM | 411.4 μL | 2.0572 mL | 4.1144 mL |
| 10 mM | 205.7 μL | 1.0286 mL | 2.0572 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 8 reference(s) in Google Scholar.)