ML-162 |
| Catalog No.GC44214 |
ML-162는 공유 글루타티온 퍼옥시다제 4(GPX4) 억제제입니다. ML-162는 돌연변이 RAS 종양 유전자 발현 세포주에 선택적 치사 효과가 있습니다
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1035072-16-2
Sample solution is provided at 25 µL, 10mM.
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ML-162 is a GPX4 inhibitor that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).[1],[2] It shares a similar structure but is more potent and selective than (1S,3R)-RSL3, a previously reported inhibitor of RAS oncogene-expressing cells.[2]
Reference:
[1]. Yang, W.S., and Stockwell, B.R. Ferroptosis: Death by lipid peroxidation. Trends Cell Biol. 26(3), 165-176 (2016).
[2]. Weïwer, M., Bittker, J.A., Lewis, T.A., et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg. Med. Chem. Lett. 22(4), 1822-1826 (2012).
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