NKL 22 (Synonyms: Histone Deacetylase Inhibitor IV) |
| Catalog No.GC32964 |
NKL 22(화합물 4b)는 HDAC1 및 HDAC3에 대해 각각 199 및 69 nM의 IC50을 갖는 히스톤 데아세틸라제(HDAC)의 강력하고 선택적인 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 537034-15-4
Sample solution is provided at 25 µL, 10mM.
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NKL 22 is a HDAC inhibitor. The value of IC 50 is 78 uM NKL 22 increase frataxin protein concentrationsNKL 22 inhibitors increase FXN mRNA in FRDA lymphocytes.HDAC inhibitors act directly on FXN. [1]
[1]. D Herman et al. Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. Nat Chem Biol, 2006 Oct, 2(10):551-8.
Average Rating: 5 (Based on Reviews and 8 reference(s) in Google Scholar.)
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