Rebeccamycin (Synonyms: BRN 4732638, NSC 359079) |
| Catalog No.GC44809 |
항종양 항생제인 레베카마이신은 DNA 토포이소머라제 I을 억제합니다. 레베카마이신은 토포이소머라제 I을 중독시켜 일차적인 항종양 효과를 발휘하는 것으로 보이며 단백질 키나제 C 및 토포이소머라제 II에는 무시할 만한 영향을 미칩니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 93908-02-2
Sample solution is provided at 25 µL, 10mM.
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Rebeccamycin is an indolocarbazole antibiotic produced by S. aerocolonigenes ATCC39243 that weakly inhibits DNA topoisomerase I. It is cytotoxic to human lung adenocarcinoma, colon carcinoma, and nasopharyngeal carcinoma cell lines (IC50s range from 0.4-98 µM), producing single-strand breaks in the DNA of these tumor cells.
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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