Rebeccamycin (Synonyms: BRN 4732638, NSC 359079) |
| Katalog-Nr.GC44809 |
Rebeccamycin, ein Antitumor-Antibiotikum, hemmt DNA-Topoisomerase I. Rebeccamycin scheint seine primÄre antineoplastische Wirkung durch Vergiftung von Topoisomerase I auszuÜben und hat eine vernachlÄssigbare Wirkung auf Proteinkinase C und Topoisomerase II.
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Cas No.: 93908-02-2
Sample solution is provided at 25 µL, 10mM.
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Rebeccamycin is an indolocarbazole antibiotic produced by S. aerocolonigenes ATCC39243 that weakly inhibits DNA topoisomerase I. It is cytotoxic to human lung adenocarcinoma, colon carcinoma, and nasopharyngeal carcinoma cell lines (IC50s range from 0.4-98 µM), producing single-strand breaks in the DNA of these tumor cells.
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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