SW155246 |
Catalog No.GC18642 |
SW155246은 hDNMT1 및 mDNMT3A에 대해 각각 1.2 및 38μM의 IC50을 갖는 DNA 메틸트랜스퍼라제(DNMT1) 선택적 억제제입니다. SW155246은 암 및 기타 질병의 연구에 사용할 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 420092-79-1
Sample solution is provided at 25 µL, 10mM.
SW155246 is an inhibitor of DNA methyltransferase 1 (DNMT1; IC50 = 1.2 μM). It is selective for human DNMT1 over murine DNMT3 (IC50 = 38 μM). SW155246 inhibits HeLa and A549 tumor cell growth in a redox-independent manner (IC50s = 8-20 μM). It also inhibits genomic methylation in HeLa cells when used at concentrations ranging from 10 to 18.6 μM.
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