Proteases

7-Methoxy obtusifolin (Compound 4) is a competitive tyrosinase inhibitor with an IC50 of 7.0 μM.

A-908292 is an effective and selective inhibitor of acetyl-CoA carboxylase 2 (ACC2), with an IC50 value of 23 nM for hACC2. A-908292 can be used in the study of fatty acid metabolism.

Ac-Ala-OH-d3 is the deuterated form of Ac-Ala-OH. Ac-Ala-OH is an endogenous metabolite.

Ac-DEVD-CMK (Caspase-3 Inhibitor III) TFA is a selective and irreversible inhibitor of caspase-3. Ac-DEVD-CMK TFA significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate (IDB; 5). Ac-DEVD-CMK TFA can be used in various experimental methods to inhibit cell apoptosis.

Acetyl-CoA Carboxylase-IN-1 is an effective inhibitor of acetyl-coenzyme A carboxylase (ACC), with an IC50 value of

Ac-VLPE-FMK is a tetrapeptide-based monofluoromethyl ketone (m-FMK) and an inhibitor of Cat-B and Cat-L. It can be used in cancer invasion research.

Ac-WEHD-AFC TFA is a fluorescent substrate for caspase-1. It can detect the fluorescence activity of caspase-1 and is used in research on tumors and inflammation.

ALDH3A1-IN-1 (Compound 18) is an effective inhibitor of ALDH3A1 with an IC50 of 1.61 μM. As a monotherapy or in combination with docetaxel, ALDH3A1-IN-1 is more effective than DEAB on primary prostate tumor epithelial cells derived from patients.

ALOX15-IN-1 (compound 8b) is an effective and selective inhibitor of rabbit and human ALOX15 linoleate oxygenase activity, with IC50 values of 0.04 μM for ALOX15 homologous substrate linoleic acid (LA) and 2.06 μM for arachidonic acid (AA).

Andecaliximab is a recombinant IgG4 monoclonal antibody that targets matrix metalloproteinase 9 (MMP9). Andecaliximab has demonstrated anti-fibrotic efficacy in a mouse model of idiopathic pulmonary fibrosis. Andecaliximab can be used for research on gastric adenocarcinoma and idiopathic pulmonary fibrosis (IPF).

AT-533 is an effective inhibitor of Hsp90 and HSV. It inhibits tumor growth and angiogenesis by blocking the HIF-1α/VEGF/VEGFR-2 signaling pathway. AT-533 also inhibits downstream pathway activation, including Akt/mTOR/p70S6K, Erk1/2, and FAK. AT-533 suppresses tube formation, cell migration, and invasion in human umbilical vein endothelial cells (HUVEC).

AXKO-0046 dihydrochloride, an indole derivative, is a selective inhibitor of LDHB. AXKO-0046 dihydrochloride has LDHB inhibitory activity with an EC50 value of 42 nM. It can be used for research on cancer metabolism.

Boc-Asp(OME)-Fluoromethyl Keton is a widely used caspase inhibitor that can inhibit Fas-mediated phagocytosis and oxidative burst inhibition, but does not affect the chemotactic activity of IL-8.

Boc-Gln-Ala-Arg-AMC acetate is a fluorescent substrate for trypsin. It can be used to measure the protein hydrolytic activity of TMPRSS2.

Bococizumab (PF-04950615) is an antibody inhibitor of human PCSK9 that can lower low-density lipoprotein cholesterol (LDL-C) levels. Bococizumab can be used in the study of hypercholesterolemia.

Bradykinin potentiator B is a venom from Agkistrodon halys blomhoffi. It is an effective ACE inhibitor and inhibits the activity of kininase II.

Cathepsin X-IN-1 (compound 25) is an effective inhibitor of tissue protease X, with an IC50 of 7.13 μM. Cathepsin X-IN-1 reduces PC-3 cell migration and has low cytotoxicity.

Cbl-b-IN-3 (Compound 23) is an inhibitor of Casitas B-lineage lymphoma proto-oncogene b (Cbl-b), with an IC50 of

Cholestenone-13C is a 13C-labeled Cholestenone. Cholestenone (4-Cholesten-3-one) is an intermediate oxidation product of cholesterol, mainly metabolized in the liver. Cholestenone has high mobility in membranes and can affect the flip-flop and efflux of cholesterol. Cholestenone may lead to long-term functional defects in cells.

Cholestenone-d5 is the deuterated form of Cholestenone. Cholestenone (4-Cholesten-3-one) is an intermediate oxidation product of cholesterol, mainly metabolized in the liver. Cholestenone has high mobility in membranes and can affect cholesterol flipping and efflux. Cholestenone may lead to long-term functional defects in cells.

Citric acid triammonium (Triammonium citrate) is formed by reacting Citric acid and ammonia in a 1:3 molar ratio. It can be used as a carbon source to prepare carbon quantum dots (CDs). Citric acid triammonium with high nitrogen content may promote the formation of nitrogen-based functional groups in CDs, thereby improving the tunable emission color of CDs.

Cofrogliptin (HSK7653) (compound 2), a tetrahydrofuran derivative, is an effective oral DPP-4 inhibitor with long-lasting blood sugar-lowering effects. Cofrogliptin (compound 2) has great potential in the treatment of type 2 diabetes mellitus (T2DM).

Creatine-d5 (monohydrate) is the deuterated form of Creatine monohydrate. Creatine monohydrate, an endogenous amino acid metabolite, plays an important role in cellular energy, especially in muscles and the brain.

Creatinine-d5 is the deuterated form of creatinine. Creatinine (NSC13123) is a breakdown product of phosphocreatine in muscles.