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Carboxypeptidase

A carboxypeptidase (CP) is an enzyme involved in the catabolism of proteins that cleaves amino acids from the C-terminal of proteins or large peptides through rapid hydrolysis at the last stages of protein cleavage. So far thirteen mammalian CPs encoded by thirteen known members of the metallocarboxypeptidase gene family and one human-specific CP (CPA3) have been identified. Based primarily on amino acid sequence similarities, metallocarboxypeptidases are divided into two subfamilies, including CPA/B family (CPA1, CPA2, CPB, MK-CPA and KPU) and CPN/E family (CPE/H, CPM, CPN, CPD, CPZ, CPX1, CPX2 and AEBP1). All members in CPA/B family are approximately 34-36 kDa proteins of optimal pH=7; while all members in CPN/E family range in size and pH optima. 

Products for  Carboxypeptidase

  1. Cat.No. Product Name Information
  2. GC60471 2-Benzylsuccinic acid 2-Benzylsuccinic acid (DL-Benzylsuccinic acid) is an potent inhibitor of carboxypeptidase A (CPA). 2-Benzylsuccinic acid  Chemical Structure
  3. GC11804 2-Guanidinoethylmercaptosuccinic Acid 2-Guanidinoethylmercaptosuccinic Acid (2-Guanidinoethylmercaptosuccinic acid) is a potent specific inhibitor of carboxypeptidase B-like processing enzyme (encephalin convertase) with the Ki value of 8.8 nM. 2-Guanidinoethylmercaptosuccinic Acid  Chemical Structure
  4. GC17937 2-MPPA glutamate carboxypeptidase II (GCP II) inhibitor 2-MPPA  Chemical Structure
  5. GC35608 Carboxypeptidase G2 (CPG2) Inhibitor Carboxypeptidase G2 (CPG2) Inhibitor is a novel Carboxypeptidase G2 (CPG2) Inhibitor, Antitumor agents. Carboxypeptidase G2 (CPG2) Inhibitor  Chemical Structure
  6. GC35741 CPA inhibitor CPA inhibitor (Carboxypeptidase inhibitor; compound 5) is a potent carboxypeptidase A (CPA) inhibitor with a Ki of 0.32 μM. CPA inhibitor  Chemical Structure
  7. GC63338 GCPII-IN-1 TFA GCPII-IN-1 TFA is a glutamate carboxypeptidase II (GCPII, or PSMA) inhibitor scaffold with a Ki of 44.3 nM. GCPII-IN-1 TFA  Chemical Structure
  8. GC13467 PMPA (NAALADase inhibitor) A potent inhibitor of GCP II/NAALADase PMPA (NAALADase inhibitor)  Chemical Structure
  9. GC18065 ZJ 43 ZJ 43  Chemical Structure

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