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D-α-Hydroxyglutaric Acid

Número de catálogo: GC18583

D-α-El Ácido hidroxiglutÁrico ((R)-2-hidroxiglutarato) es el principal metabolito que se acumula en la aciduria neurometabÓlica D-2-hidroxiglutÁrica.

D-α-Hydroxyglutaric Acid Estructura química.

Tamaño Precio Disponibilidad Cantidad
10mg
49,00 $
Disponible
25mg
93,00 $
Disponible
50mg
124,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

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Antecedentes

D-α-Hydroxyglutaric acid (D-2-HG) is an α-hydroxy acid that is over-produced in the human neurometabolic disease D-2-hydroxyglutaric aciduria (D-2-HGA). It is normally synthesized from 2-ketoglutarate (2-KG) by hydroxyacid-oxoacid transhydrogenase (HOT), although defects in HOT are not known to be associated with D-2-HGA. Instead, type I D-2-HGA involves mutations in D-2-hydroxyglutarate dehydrogenase, which converts D-2-HG back to 2-KG. Type II D-2-HGA results from gain-of-function mutations in isocitrate dehydrogenase 2 (IDH2), causing it to supplement HOT in converting 2-KG to D-2-HG. In bacteria, this α-hydroxy acid may be synthesized from oxalate and propionyl-coenzyme A by an α-hydroxyglutaric acid synthetase.

Propiedades Químicas

Cas No. 13095-47-1 SDF
Chemical Name 2R-hydroxy-pentanedioic acid
Canonical SMILES OC([C@@H](CCC(O)=O)O)=O
Formula C5H8O5 M.Wt 148.1
Solubilidad 75mg/mL in Water (Need ultrasonic); Insoluble in DMSO Storage Store at -20°C
Consejos generales Para obtener una mayor solubilidad, caliente el tubo a 37°C agítelo en el baño ultrasónico durante un rato. La solución en almaceamiento se puede almacenar por debajo de -20°C durante varios meses.
Condiciones de Envío Solución de muestra de evaluación: envíe con hielo azul
Todos los demás tamaños disponibles: envíe con RT o hielo azul a pedido

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Average Rating: 5 ★★★★★ (Based on Reviews and 21 reference(s) in Google Scholar.)

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