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D-α-Hydroxyglutaric Acid (Synonyms: D-2-HG, D-2-Hydroxyglutaric Acid)

Catalog No.GC18583

Sobreproducción en la enfermedad neurometabólica humana D-2-HGA.

Products are for research use only. Not for human use. We do not sell to patients.

D-α-Hydroxyglutaric Acid Chemical Structure

Cas No.: 13095-47-1

Tamaño Precio Disponibilidad Cantidad
10mg
49,00 $
Disponible
25mg
93,00 $
Disponible
50mg
124,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

El ácido D-α-hidroxiglurático (D-2-HG) es un ácido α-hidroxi que se produce en exceso en la enfermedad neurometabólica humana llamada aciduria D-2-hidroxiglurática (D-2-HGA). Normalmente, se sintetiza a partir de 2-cetoglutarato (2-KG) por la hidroxiácido-oxoácido transhidrogenasa (HOT), aunque no se sabe que los defectos en HOT estén asociados con D-2-HGA. En cambio, el tipo I de D-2-HGA implica mutaciones en la deshidrogenasa D-2-hidroxiglutárica, que convierte el D-2-HG de vuelta a 2-KG. El tipo II de D-2-HGA resulta de mutaciones ganadoras de función en la isocitrato deshidrogenasa 2 (IDH2), lo que hace que complemente HOT al convertir 2-KG a D-α-hidroxiglutarato. En las bacterias, este ácido α-hidroxi puede ser sintetizado a partir del oxalato y propionil-coenzima A por una sintetasa del ácido α-hidroxiglutárico.

Chemical Properties

Cas No. 13095-47-1 SDF
Sinónimos D-2-HG, D-2-Hydroxyglutaric Acid
Chemical Name 2R-hydroxy-pentanedioic acid
Canonical SMILES OC([C@@H](CCC(O)=O)O)=O
Formula C5H8O5 M.Wt 148.1
Solubility 75mg/mL in Water (Need ultrasonic); Insoluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.
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Average Rating: 5 ★★★★★ (Based on Reviews and 21 reference(s) in Google Scholar.)

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