Ebselen |
| Catalog No.GC10331 |
Ebselen (SPI-1005), un mimético de la glutatiÓn peroxidasa, es un potente bloqueador de los canales de calcio dependientes del voltaje (VDCC).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 60940-34-3
Sample solution is provided at 25 µL, 10mM.
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Ebselen (SPI-1005) is an inhibitor of HIV-1 capsid CTD dimerization[1]. Ebselen can permeate the blood-brain barrier and inhibit inositol monophosphatase (IMPase). Ebselen is a non-toxic seleno-organic drug with anti-inflammatory and antioxidant properties[2]. Ebselen inhibits QSOX1 enzymatic activity and has anticancer activity [3].
Ebselen (SPI-1005) inhibits early viral postentry events of the HIV-1 life cycle by impairing the incoming capsid uncoating process[1]. Ebselen permeates the blood-brain barrier and inhibits endogenous inositol monophosphatase in mouse brain[2].
References:
[1]. Thenin-Houssier S, et al. Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2195-208.
[2]. Singh N, et al. A safe lithium mimetic for bipolar disorder. Nat Commun. 2013;4:1332. doi: 10.1038/ncomms2320.
[3]. Hanavan PD, et al. Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic and renal cancer cell lines. Oncotarget. 2015 Jul 30;6(21):18418-28.
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)
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