Cell Cycle/Checkpoint
Cell Cycle
Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.
Targets for Cell Cycle/Checkpoint
- ATM/ATR(23)
- Aurora Kinase(17)
- Cdc42(4)
- Cdc7(3)
- Chk(14)
- c-Myc(20)
- CRM1(8)
- Cyclin-Dependent Kinases(77)
- E1 enzyme(1)
- G-quadruplex(11)
- Haspin(6)
- HMTase(1)
- Kinesin(23)
- Ksp(4)
- Microtubule/Tubulin(219)
- Mps1(15)
- Mitotic(7)
- RAD51(16)
- ROCK(60)
- Rho(13)
- PERK(10)
- PLK(33)
- PTEN(6)
- Wee1(7)
- PAK(20)
- Arp2/3 Complex(8)
- Dynamin(10)
- ECM & Adhesion Molecules(40)
- Cholesterol Metabolism(3)
- Endomembrane System & Vesicular Trafficking(26)
- G1(38)
- G2/M(26)
- G2/S(10)
- Genotoxic Stress(18)
- Inositol Phosphates(18)
- Proteolysis(99)
- Cytoskeleton & Motor Proteins(53)
- Cellular Chaperones(8)
Products for Cell Cycle/Checkpoint
- Cat.No. Nombre del producto Información
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GC40702
α-D-Galactopyranosylphenyl isothiocyanate
α-D-Galactopyranosylphenyl isothiocyanate is a chemically activated form of galactose that has been used to prepare various neoglycoproteins, which consist of a glycosylated serum albumin substituted with either fluorescein or methotrexate.
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GC41676
(±)-Nornicotine
DL-Nornicotine, (R,S)-Nornicotine
(±)-Nornicotine is a metabolite of nicotine that acts as a neuronal nicotinic acetylcholine receptor (nAChR) agonist. -
GC49482
(±)-Nornicotine-d4
DL-Nornicotine-d4, (R,S)-Nornicotine-d4
An internal standard for the quantification of (±)-nornicotine -
GC41684
(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane
BMC, Vectrase P
(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane (BMC) is a cyclohexane with two mercaptoacetamido groups. -
GC40802
(±)12(13)-DiHOME
Isoleukotoxin diol
(±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME, a cytochrome P450-derived epoxide of linoleic acid also known as isoleukotoxin.
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GC41656
(±)2-(14,15-Epoxyeicosatrienoyl) Glycerol
(±)214,15EG
2-Arachidonoyl glycerol (2-AG) is an endogenous central cannabinoid (CB1) receptor agonist that is present at relatively high levels in the central nervous system. -
GC45890
(+)-Abscisic Acid-d6
(+)-ABA-d6, Dormin-d6
(+)-Ácido abscísico-d6 (ABA-d6) es ácido abscísico marcado con deuterio. - GC62728 (1E)-CFI-400437 dihydrochloride El diclorhidrato de (1E)-CFI-400437 es un potente inhibidor de PLK4 (IC50= 0,6 nM) y selectivo frente a otros miembros de la familia PLK (>10 μM). El diclorhidrato de (1E)-CFI-400437 inhibe Aurora A, Aurora B, KDR y FLT-3 con IC50 de 0,37, 0,21, 0,48 y 0,18 μM, respectivamente. Actividad antiproliferativa.
- GC49690 (3R,5R)-Rosuvastatin (calcium salt) A potential impurity found in bulk preparations of rosuvastatin
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GC41268
(E)-2-Hexadecenal
trans-2-Hexadecenal
Sphingosine-1-phosphate (S1P), a bioactive lipid involved in many signaling processes, is irreversibly degraded by the membrane-bound S1P lyase. - GC41701 (E)-2-Hexadecenal Alkyne (E)-2-Hexadecenal alkyne is an alkyne version of the sphingolipid degradation product (E)-2-hexadecenal that can be used as a click chemistry probe.
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GC46335
(E)-Fenpyroximate
Fenpyroximate, NNI-850
El (E)-fenpiroximato es un potente acaricida. - GC10419 (R)-CCG-1423 Rho inhibitor
- GC16429 (R)-DRF053 dihydrochloride cdk/CK1 inhibitor,potent and ATP-competitive
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GC41719
(R)-nitro-Blebbistatin
R(-)7Desmethyl8nitro Blebbistatin
(R)-nitro-Blebbistatin is a more stable form of (+)-blebbistatin, which is the inactive form of (-)-blebbistatin. -
GC46347
(S)-(+)-Methoprene
Altosid, d-Methoprene, ZR 2458
El (S)-metopreno es un análogo de la hormona juvenil que impide que el insecto cambie de pupa a adulto y se usa como insecticida. -
GC41557
(S)-3'-amino Blebbistatin
(-)-3'-amino Blebbistatin, m-amino Blebbistatin, meta-amino Blebbistatin
(S)-3'-amino Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. -
GC41484
(S)-3'-hydroxy Blebbistatin
(-)-3'-hydroxy Blebbistatin, meta-hydroxy-Blebbistatin, m-hydroxy-Blebbistatin
(S)-3'-hydroxy Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. -
GC52192
(S)-4'-nitro-Blebbistatin
(-)-4'-nitro-Blebbistatin, p-nitro-Blebbistatin, para-nitro-Blebbistatin
(S)-4'-nitro-Blebbistatin es un inhibidor de miosina II no citotÓxico, fotoestable, fluorescente y especÍfico, utilizado en el estudio del papel especÍfico de la miosina II en estudios fisiolÓgicos, de desarrollo y biolÓgicos celulares. - GC14497 (S)-CCG-1423 Rho inhibitor
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GC34999
(S)-Ceralasertib
(S)-AZD6738
(S)-Ceralasertib ((S)-AZD6738) se extrae de la patente WO2011154737A1, Compuesto II, presenta una IC50 de 2,578 nM.(S)-Ceralasertib es un potente y selectivo inhibidor de ATR de sulfoximina morfolinopirimidina con excelente farmacocinética y fisicoquÍmica preclÍnica (PK ) caracterÍsticas.(S)-Ceralasertib se desarrolla mejorando la solubilidad acuosa y elimina la inhibiciÓn dependiente del tiempo de CYP3A4. - GC46351 (S)-CR8 (S)-CR8 es el isÓmero S de CR8. (S)-CR8 es un inhibidor de CDK potente y selectivo con IC50 de 0,060, 0,080, 0,11, 0,12 y 0,15 μM para CDK2/ciclina E, CDK2/ciclina A, CDK9/ciclina T, CDK5/p25 y CDK1/ciclina B, respectivamente. (S)-CR8 reduce la supervivencia de las células SH-SY5Y (IC50 0,40μM).
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GC41737
(S)-Glycyl-H-1152 (hydrochloride)
Rho Kinase Inhibitor IV
Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. -
GC40145
(S)-Laudanosine
(+)-Laudanosine, L-Laudanosine, L-(+)-Laudanosine, NSC 35045
(S)-Laudanosine is the (S) enantiomer of laudanosine, a metabolite of the neuromuscular blocking agents atracurium and cisatracurium. -
GC41739
(S)-nitro-Blebbistatin
S(-)7Desmethyl8nitro Blebbistatin
(S)-nitro-Blebbistatin is a more stable form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. -
GC18275
1,2-Dihexadecyl-sn-glycero-3-PC
1,2-Dihexadecyl-sn-glycero-3-Phosphocholine
1,2-Dihexadecyl-sn-glycero-3-PC is a synthetic ether-linked phospholipid containing hexadecyl groups at the sn-1 and sn-2 positions. - GC45783 1,2-Dioleoyl-rac-glycerol-13C3 An internal standard for the quantification of 1,2-dioleoyl-rac-glycerol
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GC46379
1,2-Dioleoyl-sn-glycero-3-PS (sodium salt)
1,2-DOPS, 18:1/18:1-PS; PS(18:1/18:1), 1,2-Dioctadecenoyl-sn-glycero-3-Phosphoserine, 1,2-Dioctadecenoyl-sn-glycero-3-Phosphatidylserine
La 1,2-dioleoil-sn-glicero-3-PS (sal de sodio) es un sustituto de la fosfoserina/fosfatidilserina. -
GC41823
1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) (sodium salt)
biotin-cap-DPPE
1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) is a biotinylated phospholipid.
- GC46385 1,3,4,6-Tetra-O-acetyl-2-azido-2-deoxy-α-D-Mannopyranose A ManNAc analog and building block
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GC19528
1,4-Benzoquinone
p-Benzoquinone, NSC 36324, p-Quinone
A toxic metabolite of benzene - GC18726 1-Methyl-1,4-dihydronicotinamide La 1-metil-1,4-dihidronicotinamida es un derivado de la nicotinamida.
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GC49736
10-acetyl Docetaxel
PNU 101383, 10-acetyl Taxotere
10-acetyl Docetaxel (10-Acetyl docetaxel) es un anÁlogo de Docetaxel, con actividad anticancerÍgena. Docetaxel es un inhibidor del desensamblaje de microtÚbulos, con actividad antimitÓtica. -
GC12954
10-DAB (10-Deacetylbaccatin)
NSC 251677
An inhibitor of microtubule assembly - GC35044 10-Deacetyl-7-xylosyl paclitaxel El 10-desacetil-7-xilosil paclitaxel es un derivado del paclitaxel (un agente estabilizador de microtÚbulos; mejora la polimerizaciÓn de la tubulina) con caracterÍsticas farmacolÓgicas mejoradas.
- GC35045 10-Oxo Docetaxel 10-Oxo Docetaxel (Docetaxel Impureza 1) es un nuevo taxoide que tiene notables propiedades antitumorales y un intermedio de Docetaxel.
- GC17295 10058-F4 10058-F4 es un inhibidor de c-Myc que previene la dimerizaciÓn y transactivaciÓn de c-Myc-Max de la expresiÓn del gen objetivo de c-Myc.
- GC63576 10074-A4 10074-A4 es un inhibidor de c-Myc. 10074-A4 podrÍa unirse a c-Myc370-409 en diferentes sitios a lo largo de la cadena peptÍdica. 10074-A4 tiene efectos anticancerÍgenos.
- GC14918 10074-G5 10074-G5 es un inhibidor de la dimerizaciÓn de c-Myc-Max con un IC50 de 146 μM.
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GC40448
12(S)-HETE
12(S)-Hydroxyeicosatetraenoic Acid
12(S)-HETE is the predominant lipoxygenase product of mammalian platelets.
- GC46434 13C15-Nivalenol An internal standard for the quantification of nivalenol
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GC49390
13C6-4-Nitroaniline
13C6-p-Nitroaniline
An internal standard for the quantification of 4-nitroaniline - GC41110 16-epi Latrunculin B 16-epi Latrunculin B, first isolated from the Red Sea sponge N.
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GC48423
19-O-Acetylchaetoglobosin A
Chaetoglobosin A Acetate
La 19-O-acetilquetoglobosina A, un alcaloide del citocalasano, es un metabolito fÚngico aislado originalmente de C. globosum que tiene actividades inhibidoras de la polimerizaciÓn de actina y citotÓxicas. La 19-O-acetilquetoglobosina A es citotÓxica para las células de cÁncer de cuello uterino HeLa. -
GC42151
2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)
dGMP
2'-Deoxyguanosine 5'-monophosphate (dGMP) is used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis. -
GC40947
2,3-Dimethoxy-5-methyl-p-benzoquinone
Coenzyme Q0, CoQ0
La 2,3-dimetoxi-5-metil-p-benzoquinona (CoQ0) es un compuesto de ubiquinona activo oral potente que puede derivarse de Antrodia cinnamomea. -
GC49671
2,3-Oxidosqualene
(3R,S)-Oxidosqualene, Squalene 2,3-oxide
An intermediate in the biosynthesis of sterols -
GC45324
2,5-dimethyl Celecoxib
DMC
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GC49362
2-Amino-3,8-dimethylimidazo-[4,5-f]-quinoxaline
MeIQx
A food-derived carcinogen -
GC52029
2-Aminoflubendazole
Hydrolyzed Flubendazole
El 2-aminoflubendazol es el metabolito de los bencimidazoles. - GC40675 2-deoxy-Artemisinin 2-deoxy-Artemisinin is an inactive metabolite of the antimalarial agent artemisinin.
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GC15084
2-Methoxyestradiol (2-MeOE2)
2Hydroxyestradiol 2methyl ether, 2ME2, NSC 659853, Panzem
2-Methoxyestradiol (2-MeOE2/2-Me) is a HIF-1α inhibitor that inhibits HIF-1α accumulation and HIF transcriptional activity. 2-Methoxyestradiol can trigger p53-induced apoptosis and has potential antitumor activity.. -
GC52140
2-Methoxyhydroquinone
o-Methoxyhydroquinone, MHQ, MOHQ
- GC42161 2H-Cho-Arg (trifluoroacetate salt) 2H-Cho-Arg is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection.
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GC40618
3',4',7-Trihydroxyisoflavone
3'-hydroxy Daidzein, 3’,4’,7-THIF
3',4',7-trihidroxiisoflavona, un metabolito principal de la daidzeÍna, es un inhibidor competitivo de ATP de Cot (Tpl2/MAP3K8) y MKK4. 3',4',7-trihidroxiisoflavona tiene actividades anticancerÍgenas, antiangiogénicas, quimioprotectoras y de eliminaciÓn de radicales libres. -
GC45332
3'-Dephosphocoenzyme A
depCoA, Dephospho-CoA
An intermediate in the biosynthesis of CoA -
GC42239
3,6-diacetoxy Phthalonitrile
ADB, 1,4-Diacetoxy-2,3-dicyanobenzene, 2,3-Dicyano-1,4-hydroquinone diacetate
El 3,6-diacetoxi ftalonitrilo es una sonda fluorescente permeable a las células. -
GC12314
3-(4-Pyridyl)indole
Rho Kinase Inhibitor III,ROCK Inhibitor III,Rockout
El 3-(4-piridil)indol (Rockout) es un inhibidor de la Rho-quinasa (ROCK), con una IC50 de 25 μM. -
GC46582
3-Acetyldeoxy Nivalenol-13C17
3-AcDON-13C17, DON 3-acetate-13C17, Deoxy Nivalenol-3-acetate-13C17
An internal standard for the quantification of 3-acetyldeoxy nivalenol -
GC52129
3-Amino-5-hydroxybenzoic Acid
AHBA
- GC15389 360A
- GC10115 360A iodide
- GC14186 3MB-PP1 3MB-PP1, un anÁlogo de purina voluminoso, es un inhibidor de la quinasa 1 similar a Polo (Plk1).
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GC45354
4β-Hydroxywithanolide E
NSC 212509
4β-Hydroxywithanolide E, aislado de Physalis peruviana L. -
GC17271
4'-Demethylepipodophyllotoxin
(-)-4′-Demethylepipodophyllotoxin
An inhibitor of tubulin polymerization -
GC46606
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaboran-2yl)aniline
4-Aminophenylboronic Acid pinacol ester
A heterocyclic building block -
GC46635
4-deoxy Nivalenol-13C15
Vomitoxin-13C15, Deoxynivalenol-13C15, DON-13C15
An internal standard for the quantification of 4-deoxy nivalenol - GC18359 4-Epianhydrochlortetracycline (hydrochloride) 4-Epianhydrochlortetracycline is a derivative of tetracycline .
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GC42449
4-Methylumbelliferyl-α-L-Iduronide (free acid)
4-Methylumbelliferyl-α-L-Idopyranosiduronic Acid, 4-MU-α-IdoA, MU-α-IdoA
4-Methylumbelliferyl-α-L-iduronide (free acid) is a fluorogenic substrate for α-L-iduronidase, an enzyme found in cell lysosomes that is involved in the degradation of glycosaminoglycans such as dermatan sulfate and heparin sulfate. -
GC49244
4-oxo Isotretinoin
Ro 22-6595
An active metabolite of isotretinoin -
GC52365
4-tert-Octylphenol monoethoxylate
NSC 5259, OP1EO
An alkylphenolethoxylate and a degradation product of non-ionic surfactants -
GC52227
5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone
(±)-δ-(3,4-Dihydroxyphenyl)-γ-Valerolactone, 5-(3',4'-Dihydroxyphenyl)-γ-VL
An active metabolite of various polyphenols -
GC46681
5-Bromouridine
(–)-5-Bromouridine, BrU, BrUrd, NSC 38296
A brominated uridine analog - GC45357 5-Chlorouracil
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GC41156
5-Octyl D-glutamate
5-Octyl ester D-glutamatic acid
5-Octyl D-glutamate, also known as 5-octyl ester D-glutamate, is a stable, cell-permeable molecule that generates free D-glutamate upon hydrolysis of the ester bond by cytoplasmic esterases. -
GC41423
5-trans Prostaglandin E2
transDinoprostone, 5,6trans PGE2
5-trans PGE2 occurs naturally in some gorgonian corals and is a common impurity in commercial lots of PGE1. -
GC42586
6α-hydroxy Paclitaxel
6α-hydroxy Taxol
6α-hidroxi Paclitaxel es un metabolito primario de Paclitaxel. 6α-hidroxi Paclitaxel conserva un efecto dependiente del tiempo sobre los polipéptidos transportadores de aniones orgÁnicos 1B1/SLCO1B1 (OATP1B1) con una potencia de inhibiciÓn similar a Paclitaxel, mientras que ya no mostrÓ inhibiciÓn dependiente del tiempo de OATP1B3. 6α-hidroxi Paclitaxel se puede utilizar para la investigaciÓn del cÁncer. - GC45969 6β-hydroxy Eplerenone A major metabolite of eplerenone
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GC46721
6-Chloro-2-fluoropurine
NSC 37363
A heterocyclic building block -
GC48721
6-O-Demethyl Griseofulvin
6-Demethylgriseofulvin
A metabolite of griseofulvin - GC15478 6H05 6H05 es un inhibidor selectivo y alostérico del mutante oncogénico K-Ras (G12C).
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GC40202
7α-hydroxy Cholesterol-d7
7α-hydroxycholesterol-d7
7α-hydroxy Cholesterol-d7 is intended for use as an internal standard for the quantification of 7α-hydroxy cholesterol by GC- or LC-MS.
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GC46733
7,12-Dimethylbenz[a]anthracene
DMBA
El 7,12-dimetilbenz[a]antraceno tiene actividad cancerÍgena como hidrocarburo aromÁtico policÍclico (HAP). El 7,12-dimetilbenz[a]antraceno se usa para inducir la formaciÓn de tumores en varios modelos de roedores. - GC35188 7-Epi-10-oxo-docetaxel 7-Epi-10-oxo-docetaxel (Docetaxel Impureza 2) es una impureza de docetaxel detectada por cromatografÍa lÍquida de alta resoluciÓn (HPLC).
- GC35189 7-Epi-docetaxel 7-Epi-10-oxo-docetaxel (Docetaxel Impureza C; 7-Epitaxotere) es una impureza de docetaxel.
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GN10625
7-Epitaxol
7-epi Taxol
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GC42610
7-hydroxy Pestalotin
LL-P880β
La 7-hidroxi pestalotina (LL-P880β) es un metabolito fúngico. -
GC42616
7-oxo Staurosporine
BMY 41950, RK-1409
7-oxo Staurosporine is an antibiotic originally isolated from S.
- GC35197 7-xylosyltaxol 7-xilosiltaxol (taxol-7-xilÓsido) es un derivado de taxol (paclitaxel); Paclitaxel se une a la tubulina e inhibe el desmontaje de los microtÚbulos.
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GC52126
8-chloro Caffeine
NSC 6277
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GC40844
9-(2,2-Dicyanovinyl)julolidine
DCVJ, 9-Julolidine Methylene Malononitrile, NSC 160064
La 9-(2,2-Dicianovinil)julolidina (9-(2,2-Dicianovinil)julolidina), un rotor molecular y un tinte fluorescente Único, se une a la tubulina y la actina y aumenta drÁsticamente la intensidad de su fluorescencia tras la polimerizaciÓn. -
GC48986
9-hydroxy Stearic Acid
9-HSA, 9-hydroxy Octadecanoic Acid
A hydroxy fatty acid -
GC42665
AAF-CMK (trifluoroacetate salt)
NAlaAlaPheCMK, Tripeptidyl Peptidase Inhibitor II
Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides. - GC35216 AAPK-25 AAPK-25 es un inhibidor dual Aurora/PLK potente y selectivo con actividad antitumoral, que puede provocar un retraso mitÓtico y detener las células en una prometafase, reflejada por la fosforilaciÓn de la histona H3Ser10 del biomarcador y seguida de un aumento de la apoptosis. AAPK-25 se dirige a Aurora-A, -B y -C con valores de Kd que oscilan entre 23 y 289 nM, asÍ como a PLK-1, -2 y -3 con valores de Kd que oscilan entre 55 y 456 nM.
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GC25025
Abraxane
Nab-Paclitaxel
Abraxane (Nab-Paclitaxel), a novel solvent-free taxane with the binding ratio of Paclitaxel to human serum albumin of 1:9, is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimer and inhibits microtubule depolymerization to stabilize the microtubule system. - GC15875 ABT-751 (E7010) ABT-751 (E7010)(E 7010) es una nueva sulfonamida antimitÓtica y fijadora de tubulina biodisponible con IC50 de aproximadamente 1,5 y 3,4 μ M en lÍneas celulares de neuroblastoma y no neuroblastoma, respectivamente.
- GC42683 Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human neutrophil elastase (kcat/Km = 531 mM-1s-1).
- GC52499 Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp (trifluoroacetate salt) A sensitive substrate for neutrophil elastase
- GC42684 Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp (trifluoroacetate salt) Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human proteinase 3 (kcat/Km = 1,570 mM-1s-1).
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GA20494
Ac-Asp-Glu-Val-Asp-pNA
Ac-Asp-Glu-Val-Asp-pNA
The cleavage of the chromogenic caspase-3 substrate Ac-DEVD-pNA can be monitored at 405 nm.