1,3,7-Trimethyluric Acid (Synonyms: 8-oxo Caffeine, NSC 11259) |
| Katalog-Nr.GC41837 |
1,3,7-TrimethylursÄure ist der Metabolit von Koffein. Das metabolische VerhÄltnis von 1,3,7-TrimethylursÄure zu Koffein kann als Biomarker zur Beschreibung der VariabilitÄt der CYP3A-AktivitÄt in einer Kohorte ausgewertet werden.
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Cas No.: 5415-44-1
Sample solution is provided at 25 µL, 10mM.
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1,3,7-Trimethyluric acid is a methyl derivative of uric acid and a product of C-8 oxidation of caffeine by cytochrome P450 enzymes. It can be detected in urine as a marker of caffeine consumption.
Reference:
[1]. Tassaneeyakul, W., Birkett, D.J., McManus, M.E., et al. Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms. Biochem. Pharmacol. 47(10), 1767-1776 (1994).
[2]. Bhat, V.B., Sridhar, G.R., and Madyastha, K.M. Efficient scavenging of hydroxyl radicals and inhibition of lipid peroxidation by novel analogues of 1,3,7-trimethyluric acid. Life Sci. 70(4), 381-393 (2001).
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