β-Amyrone (Synonyms: β-Amyron) |
| Katalog-Nr.GC66340 |
β-Amyron (β-Amyron) ist eine Triterpenverbindung, die entzÜndungshemmende Wirkung hat, indem sie die Expression von COX-2 hemmt. β-Amyrone hat eine antimykotische AktivitÄt sowie eine antivirale AktivitÄt gegen das Chikungunya-Virus. β-Amyron hemmt auch die AktivitÄt von α-Glucosidase und Acetylcholinesterase (AChE). β-Amyrone kann bei der Erforschung von Krankheiten wie EntzÜndungen, Infektionen und Fettleibigkeit eingesetzt werden.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 638-97-1
Sample solution is provided at 25 µL, 10mM.
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β-Amyrone (β-Amyron) is a triterpene compound which has anti-inflammatory activity through inhibiting the expression of COX-2. β-Amyrone has antifungal activity , as well as antiviral activity against Chikungunya virus. β-Amyrone also inhibits α-glucosidase and acetylcholinesterase (AChE) activity. β-Amyrone can be used in the research of disease like inflammation, infection, and obesity[1][2][3][4].
β-Amyrone (1.25-10 μg/mL, 24 h) inhibits on NO? production in LPS-stimulated J774 cells, with an IC50 value of 4.61 μg/mL, and has no obvious effect on cell viability[1].
β-Amyrone (10 μg/mL, 24 h) inhibits IL-6, IL-10 levels, and COX-2 expression in LPS-stimulated J774 cells[1].
β-Amyrone (0-235 μM, 7days) has antiviral activity in Vero cells against Chikungunya virus (CHIKV), with EC50 value of 86 uM[2].
β-Amyrone inhibits α-glucosidase, acetylcholinesterase (AChE) and fungal activity with IC50 values of 25 μM, 23 μM and 8 μg/mL, respectively[4].
Western Blot Analysis[1]
| Cell Line: | LPS (1 μg/mL)-stimulated J774 cells |
| Concentration: | 2.5, 5, 10 μg/mL |
| Incubation Time: | 24 h |
| Result: | Inhibited COX-2 expression in a concentration-dependent manner (approximately 90% reduction at 5 or 10 μg/ mL). |
β-Amyrone (local administration on ear, 0.1-0.6 mg/kg, a single dose) inhibits ear edema formation in phenol-induced edema mice[1].
| Animal Model: | Ear phenol-induced edema in Balb C mice[1] |
| Dosage: | 0.1, 0.3, 0.6 mg/kg, a single dose |
| Administration: | Local administration (20 ??L solution) on ear |
| Result: | Inhibited ear edema formation in a dose-related manner (47% inhibition at the dose of 0.6mg/kg). |
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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