Antihistamine-1 |
| Katalog-Nr.GC31141 |
Antihistamin-1 ist ein H1-Antihistamin (Ki = 6,9 nM) mit akzeptabler Durchdringung der Blut-Hirn-Schranke und auch ein Inhibitor von CYP2D6 und des hERG-Kanals mit IC50-Werten von 5,4 bzw. 0,8 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1186430-60-3
Sample solution is provided at 25 µL, 10mM.
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Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively.
Antihistamine-1 (Compound 2) is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively[1].
[1]. Lavrador-Erb K, et al. The discovery and structure-activity relationships of 2-(piperidin-3-yl)-1H-benzimidazoles as selective, CNS penetrating H1-antihistamines for insomnia. Bioorg Med Chem Lett. 2010 May 1;20(9):2916-9.
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
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