Lung cancer is one of the cancers with the highest mortality rate in the world, and non-small cell lung cancer (NSCLC), as its main type, threatens people's health and longevity. Medical experts have carried out a lot of basic research on lung cancer, and have also developed many targeted drugs, but the changes in the disease are always one step ahead, and more new drugs and treatment strategies are urgently needed to deal with it.

Since its discovery in 1979, the p53 gene has been one of the focuses of oncology research. Searching the Pubmed database with p53 as the keyword can find more than 100,000 articles. In a 2017 statistic by Nature magazine, the p53 gene ranked first in the list of the most popular research genes in the past few decades by an absolute advantage.