BRD9539 |
| Katalog-Nr.GC32988 |
BRD9539 ist ein Histon-Methyltransferase-G9a-Inhibitor mit einem IC50-Wert von 6,3 μM. BRD9539 hemmt auch die PRC2-AktivitÄt und ist gegen SUV39H1, NSD2 und DNMT1 inaktiv.
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Cas No.: 1374601-41-8
Sample solution is provided at 25 µL, 10mM.
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BRD9539 inhibits G9a activity with an IC50 of 6.3 μM, inhibits PRC2 activity with a similar IC50.target: G9a, PRC2;IC50: 6.3 μM ( G9a ), 6.3 uM ( PRC2 ); BRD9539 is a more potent biochemical inhibitor than its methyl-ester analogue BRD4770, with 20% remaining G9a activity compared to 45% of BRD4770 at screening concentration.
[1]. Yuan Y et al. A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma. ACS Chem Biol. 2012 Jul 20;7(7):1152-7.
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