Carboxylesterase-IN-2 |
| Katalog-Nr.GC65165 |
Carboxylesterase-IN-2 (Verbindung 4u) ist ein potenter Inhibitor von Carboxylesterase Notum mit einem IC50 von weniger als oder gleich 10 nM. Notum ist ein negativer Regulator der Wnt-Signalgebung, der durch die Hydrolyse eines Palmitoleoylatesters wirkt, der fÜr die Wnt-AktivitÄt erforderlich ist. Carboxylesterase-IN-2 hat das Potenzial fÜr die Erforschung von Krebserkrankungen.
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Cas No.: 2764748-88-9
Sample solution is provided at 25 µL, 10mM.
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Carboxylesterase-IN-2 (compound 4u) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-2 has the potential for the research of cancer disease[1].
[1]. Steadman D, et al. Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. J Med Chem. 2022;65(1):562-578.
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