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NBDHEX

Katalog-Nr.GC39315

NBDHEX ist ein potenter Inhibitor der Glutathion-S-Transferase P1-1 (GSTP1-1). NBDHEX induziert die Apoptose von Tumorzellen. NBDHEX wirkt als Antikrebsmittel, indem es die katalytische AktivitÄt von GST hemmt, die Unannehmlichkeiten der Extrusion des Inhibitors aus der Zelle durch spezifische Pumpen vermeidet und die Wechselwirkung zwischen GSTP1-1 und wichtigen Signaleffektoren stÖrt. NBDHEX kann auch als SpÄtphasen-Autophagie-Inhibitor wirken.

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NBDHEX Chemische Struktur

Cas No.: 787634-60-0

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10mM (in 1mL DMSO)
92,00 $
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5mg
83,00 $
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10mg
139,00 $
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50mg
417,00 $
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100mg
695,00 $
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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

NBDHEX is a potent glutathione S-transferase P1-1 (GSTP1-1) inhibitor. NBDHEX induces apoptosis of tumor cells. NBDHEX acts as an anticancer agent by inhibiting GSTs catalytic activity, avoiding inconvenience of the inhibitor extrusion from the cell by specific pumps and disrupting the interaction between the GSTP1-1 and key signaling effectors. NBDHEX can also act as late-phase autophagy inhibitor[1][2].

[1]. Sha HH, et al. 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol: a promising new anticancer compound. Biosci Rep. 2018 Feb 13;38(1). pii: BSR20171440. [2]. Filomeni G, et al. 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol, a specific glutathione S-transferase inhibitor, overcomes the multidrug resistance (MDR)-associated protein 1-mediated MDR in small cell lung cancer. Mol Cancer Ther. 2008 Feb;7(2):371-9. [3]. Pellizzari Tregno F, et al. In vitro and in vivo efficacy of 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) on human melanoma. Eur J Cancer. 2009 Sep;45(14):2606-17.

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