PRGL493 |
| Katalog-Nr.GC47973 |
PRGL493 ist ein potenter und selektiver Inhibitor der langkettigen Acyl-CoA-Synthetase 4 (ACSL4). PRGL493 blockiert die Zellproliferation und das Tumorwachstum sowohl in Brust- als auch in Prostatazell- und Tiermodellen. PRGL493 wird fÜr die Krebsforschung verwendet.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2479378-45-3
Sample solution is provided at 25 µL, 10mM.
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PRGL493 is an inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4).1 It inhibits formation of arachidonoyl-CoA (AA-CoA) from arachidonic acid in, as well as the proliferation and migration of, PC3 and MDA-MB-231 cancer cells when used at a concentration of 50 µM. PRGL493 (5 µM) reduces production of progesterone induced by 8-Br-cyclic AMP (8-Br-cAMP) in MA-10 Leydig tumor cells. It inhibits tumor growth in a PC3 mouse xenograft model when administered at a dose of 0.25 mg/kg.
1.Castillo, A.F., Orlando, U.D., Maloberti, P.M., et al.New inhibitor targeting Acyl-CoA synthetase 4 reduces breast and prostate tumor growth, therapeutic resistance and steroidogenesisCell. Mol. Life Sci.(2020)
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