15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α (Synonyms: 15-(6-nitroxyhexanoyl)-17-phenyl trinor PGF2α, 15-(6-nitroxyhexanoyl)-Bimatoprost, NCX 470) |
| Katalog-Nr.GC49036 |
A nitric oxide-donating derivative of 17-phenyl trinor prostaglandin F2α
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1194396-71-8
Sample solution is provided at 25 µL, 10mM.
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15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α (15-(6-nitroxyhexanoyl)-17-phenyl trinor PGF2α) is a nitric oxide-donating derivative of 17-phenyl trinor PGF2α .1 It increases cGMP levels in rabbit aqueous humor and iris ciliary body when topically administered at a concentration of 0.042%. Topical administration of 15-(6-nitroxylhexanoyl)-17-phenyl trinor PGF2α (0.14%) reduces intraocular hypertension (IOP) in a rabbit model of hypertonic saline-induced transient ocular pressure. It also reduces IOP in a cynomolgus monkey model of laser-induced ocular hypertension when administered topically at a concentration of 0.042%.
1.Impagnatiello, F., Toris, C.B., Batugo, M., et al.Intraocular pressure-lowering activity of NCX 470, a novel nitric oxide-donating bimatoprost in preclinical modelsInvest. Ophthalmol. Vis. Sci.56(11)6558-6564(2015)
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