NSC 756093 |
| Katalog-Nr.GC49412 |
NSC 756093 ist ein potenter Inhibitor der GBP1:PIM1-Interaktion. NSC 756093 kann möglicherweise die Resistenz gegen Paclitaxel rückgängig machen. NSC 756093 kann für die Eierstockkrebsforschung verwendet werden.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1629908-92-4
Sample solution is provided at 25 µL, 10mM.
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NSC 756093 is an inhibitor of the protein-protein interaction between guanylate binding protein 1 (GBP1) and the serine/threonine kinase Pim-1.1 It binds to GBP1-Pim-1 (Kd = 38 nM) and inhibits the interaction by 65% when used at a concentration of 100 nM. NSC 756093 enhances radiation-induced cytotoxicity in FaDu hypopharyngeal carcinoma cells (IC50 = 496 nM), as well as induces apoptosis and cell cycle arrest at the G2/M phase in the same cells.2
1.Andreoli, M., Persico, M., Kumar, A., et al.Identification of the first inhibitor of the GBP1:PIM1 interaction. Implications for the development of a new class of anticancer agents against paclitaxel resistant cancer cellsJ. Med. Chem.57(19)7916-7932(2014) 2.Resendez, A., Tailor, D., Graves, E., et al.Radiosensitization of head and neck squamous cell carcinoma (HNSCC) by a podophyllotoxinACS Med. Chem. Lett.10(9)1314-1321(2019)
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