- Bestell-Nr. Artikelname Informationen
- GA20742 Amyloid β-Protein (17-40) Cleavage of APP by alpha- and gamma-secretase (i.e. the non-amyloidogenic pathway) yields p3 peptide, a mix of Aβ 17-40 and Aβ 17-42. p3 is a major constituent of diffuse plaques observed in AD brains and pre-amyloid plaques in people affected by Down syndrome.
- GA20738 Amyloid β-Protein (1-6) Experiments using sub-peptides of Aβ42 revealed that the epitope identified by the antibody A8, as described by Ying and coworkers, lies within the 1-6 region of Aβ. The antibody displays high affinity for soluble Aβ42 oligomers in the molecular weight range of 16.5-25 kDa, and detected target antigen in brain sections from senescence-accelerated SAMP 8 mice.
- GA20722 Amyloid β-Protein (1-14) The N-terminal Aβ fragments Aβ1-14, Aβ1-15 (H-6368), and Aβ1-16 (H-2958) are elevated in cell media and in CSF in response to γ-secretase inhibitor treatment. The presence of these small peptides is consistent with a catabolic amyloid precursor protein cleavage pathway by β- followed by α-secretase. It has been shown that Aβ1-14, Aβ1-15, and Aβ1-16 increase dose-dependently in response to γ-secretase inhibitor treatment while Aβ1-42 levels are unchanged.
- GA20718 Amyloid β/A4 Protein Precursor₇₇₀ (667-676) The peptide substrate APP (667-676), SEVKMDAEFR, corresponds to the wild-type amyloid precursor protein (APP) β-secretase cleavage site. SEVKMDAEFR has been used for assaying β-secretase activity.
- GA20572 Ac-Gly-Lys-OMe Substrate for the determination of urokinase activity. It is also cleaved by thrombin, plasmin and trypsin as well as complement component C3/C5 convertases. Also known as GK-peptide, used in studies on protein glycation and formation of Maillard products.
- GA20534 Acetyl-Amyloid β-Protein (15-20) amide Incubation of Ac-QKLVFF-NH? with the amyloid β-protein (1-40) inhibited polymerization of the amyloid β-protein (1-40) into amyloid fibrils. The peptide is thought to block the polymerization sites.
- GA20283 (Pyr³)-Amyloid β-Protein (3-40) The pyroglutamate-modified amyloid-β peptides derived from Aβ40 (H-7422) and Aβ42 (H-4796) have gained considerable attention as potential key participants in the pathology of Alzheimer's disease (AD) due to their abundance in AD brain, high aggregation propensity, stability, and cellular toxicity. Aβ40 and 42 can be N-terminally truncated by action of cathepsin B. The cyclization of Glu³ is catalyzed by glutaminyl cyclase. Hence, inhibition of these enzymes could be a therapeutic approach to AD.
- GA20282 (Pyr¹¹)-Amyloid β-Protein (11-40) pEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV, the N-terminally truncated isoform of the amyloid β-protein (Aβ) beginning with a pyroglutamate (Pyr) residue at position 11 was used in experiments studying the generality of fibrillogenesis-related helix formation. Comparing the fibrillogenesis kinetics of many of the most important clinically relevant amyloid β-protein alloforms it could be observed that among these peptides (Pyr¹¹)-amyloid β-protein (11-40) exhibited the greatest retardation of fibrillization rate.
- GA20259 (Nle³⁵)-Amyloid β-Protein (1-40) The reactive thioether of Met³? is crucial for the activity of Aβ 1-40 and Aβ 1-42. Due to the replacement of Met by inert Nle, M35Nle Aβ 1-40 was no longer toxic to cultured hippocampal neurons and had little effect on the level of protein carbonyl residues. The Nle peptide showed the same propensity to aggregate, whereas sulfoxide formation hindered the required conformational transition from random coil to β-sheet.
- GA20200 (Gly²²)-Amyloid β-Protein (1-42) The arctic mutant of amyloid β peptide 1-42, in which Glu²² is substituted by Gly, is distinctly more amyloidogenic than the wild-type Aβ 1-42.
- GA20197 (Gly²¹)-Amyloid β-Protein (1-40) Contrary to β-amyloid peptides mutated at position 22 (Dutch, Italian, Arctic mutants) the Flemish mutation (A21G) shows a decreased tendency to aggregate and a reduced neurotoxicity. In the studies of Betts and Tsubuki, A21G was degraded significantly more slowly by neprilysin than the wild-type Aβ 1-40 and the E22 mutants. The relative resistance to proteolytic degradation may account for the pathogenicity of the Aβ mutant.
- GA20184 (Gln²²,Asn²³)-Amyloid β-Protein (1-40) Transgenic mice expressing the vasculotropic Dutch/Iowa (E693Q/D694N) mutant human Aβ precursor protein in brain (Tg-SwDI) accumulate abundant cerebral microvascular fibrillar amyloid deposits and exhibit robust neuroinflammation. In vitro, the doubly mutated Aβ peptides showed an increased propensity to fibrillation and pathogenicity compared to the Dutch and Iowa single mutants.
- GA20050 (Cys⁰)-Amyloid β-Protein (1-40) Cys-Aβ1-40 can be easily and selectively modified, labeled, coupled to carriers e.g. by maleimide chemistry without affecting the sequences involved in fibril formation. The free mercapto moiety of the peptide adheres to gold surfaces.
- GA20042 (Asn⁷)-Amyloid β-Protein (1-40) The Tottori (D7N) mutation of β-amyloid peptides accelerates fibrillation without increasing protofibril formation. Ono et al. showed that the English and Tottori mutations alter Abeta assembly at its earliest stages, monomer folding and oligomerization, and produce oligomers that are more toxic to cultured neuronal cells than are wild type oligomers.
- GA20041 (Asn⁶⁷⁰,Sta⁶⁷¹,Val⁶⁷²)-Amyloid β/A4 Protein Precursor₇₇₀ (662-675) Amyloid precursor protein (APP) β-secretase from human brain cleaves full-length APP at the amino terminus of the amyloid β-protein (Aβ) sequence, thus leading to the generation and extracellular release of β-cleaved soluble APP and a corresponding cell-associated carboxy-terminal fragment. The subsequent cleavage of the C-terminal fragment by γ-secretase(s) leads to the formation of Aβ. This new peptide represents a potent substrate analog inhibitor of APP β-secretase with IC?? = 30 nM.
- GA20040 (Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (667-676) This peptide substrate corresponds to the 'Swedish' Lys-Met/Asn-Leu (K670N/M671L) mutation of the amyloid precursor protein (APP) β-secretase cleavage site. It has been used for assaying β-secretase activity.
- GA20039 (Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (667-675) SEVNLDAEF corresponds to the mutant junctional sequence of the amyloid precursor protein (APP) found in a Swedish family with early-onset Alzheimer's disease, therefore referred to as the 'Swedish' mutation (K670N/M671L). The peptide has been used for assaying cleavage at leucine-aspartate by cathepsin G and chymotrypsin, whereas neither cathepsin B, D nor L generated any products.
- GA20029 (Arg¹³)-Amyloid β-Protein (1-40) H13R, a mutation in the metal-binding region of Abeta reduces its copper-mediated toxicity. The native rodent sequence containing an arginine at this position is more tolerant to metals than the human amyloid peptide.
- GC45565 Semax
- GC45490 Kisspeptin-54 (human) (trifluoroacetate salt)
- GC45489 K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt)
- GC45462 GLP-1 (1-36) amide (human, rat) (trifluoroacetate salt)
- GC45434 Dipeptide diaminobutyroyl benzylamide (acetate)
- GC35641 CEF19, Epstein-Barr Virus latent NA-3A 458-466 CEF19, Epstein-Barr-Virus latent NA-3A 458-466 ist ein einzelnes Peptidepitop, YPLHEQHGM, das die Reste 458-466 des Kernantigen-3A-Proteins des Epstein-Barr-Virus (EBV) vom Typ 1 (Stamm B95.8) darstellt.
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GC19550
LL-37, Human TFA
LL-37, Human TFA is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide
- GC45234 β-Endorphin (1-27) (human) (trifluoroacetate salt) β-Endorphin (1-27) is an endogenous peptide that binds to μ-, δ-, and κ-opioid receptors (Kis = 5.31, 6.17, and 39.82 nM, respectively, in COS-1 cells expressing rat receptors).
- GC45231 β-Defensin-4 (human) (trifluoroacetate salt) β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.
- GC45230 β-Defensin-3 (human) (trifluoroacetate salt) β-Defensin-3 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.
- GC45139 Vapreotide (trifluoroacetate salt) Vapreotide is a peptide neurokinin-1 receptor (NK1) antagonist and analog of somatostatin (IC50 = 330 nM in a radioligand binding assay).
- GC45130 Urodilatin Urodilatin is a renal natriuretic peptide first isolated from human urine.
- GC45096 Tyr-α-CGRP (human) (trifluoroacetate salt) Tyr-α-CGRP is an N-terminal extended tyrosinated analogue of α-calcitonin gene-related peptide.
- GC45062 TNF-α Antagonist TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor.
- GC44914 Somatostatin-14 (acetate) Somatostatin-14 is a natural cyclic peptide hormone derived from the preprohormone, somatostatin.
- GC44821 Reversin 121 Reversin 121 is a hydrophobic peptide chemosensitizer that can reverse P-glycoprotein-mediated multidrug resistance.
- GC44674 Pramlintide (acetate hydrate) Pramlintide is a non-amyloidogenic analog of the antidiabetic peptide hormone amylin that contains proline residues substituted at positions 25, 28, and 29.
- GC44558 PAR3 (1-6) (human) PAR3 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 1 (PAR1) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR3 and residues 39-44 of the full-length human sequence.
- GC44557 PAR2 (1-6) (mouse, rat) PAR2 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of mouse and rat PAR2.
- GC44533 PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt) Pituitary adenylate cyclase-activating peptide (PACAP) (6-27) is a PACAP receptor antagonist with IC50 values of 1,500, 600, and 300 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expressed in CHO cells.
- GC44531 PACAP (1-27) (human, mouse, ovine, porcine, rat) (trifluoroacetate salt) Pituitary adenylate cyclase-activating peptide (PACAP) (1-27) is a PACAP receptor agonist with IC50 values of 3, 2, and 5 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expressed in CHO cells.
- GC44526 Oxytocin (acetate) Oxytocin (Acetat) ist ein pleiotropes, hypothalamisches Peptid, das dafür bekannt ist, Geburt, Laktation und prosoziales Verhalten zu erleichtern.
- GC44518 Osteocalcin (1-49) (human) (trifluoroacetate salt) Osteocalcin (1-49) is a non-collagenous peptide that is secreted by osteoblasts and odontoblasts and comprises 1-2% of the total protein in bone.
- GC44484 Obestatin (rat) (trifluoroacetate salt) Obestatin is a 23-amino acid peptide hormone that is formed by cleavage of the ghrelin and obestatin prepropeptide.
- GC44388 NF-κB Control NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence (NLS) of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells.
- GC44374 Neuromedin B (trifluoroacetate salt) Neuromedin B (NMB) is a peptide agonist of the NMB receptor (Ki = 7.4 nM in NCI-H1299 small cell lung cancer cells expressing the human receptor).
- GC44257 Myelin Basic Protein (87-99) (human, bovine, rat) (trifluoroacetate salt) Myelin basic protein (MPB) (87-99) is an encephalitogenic peptide.
- GC44235 MMP Inhibitor I (trifluoroacetate salt) MMP inhibitor I is a peptide inhibitor of matrix metalloproteinase-1 (MMP-1), MMP-2, and MMP-3 (IC50s = 1.3, 30, and 150 μM, respectively).
- GC44078 LL-37 amide (trifluoroacetate salt) LL-37 is a cationic and α-helical antimicrobial peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and is upregulated in psoriatic lesions.
- GC44034 Lariatin A Lariatin A is an antimycobacterial lasso peptide originally isolated from R.
- GC44032 Lanreotide (acetate) Lanreotide is a peptide analog of somatostatin that binds to somatostatin receptors (SSTRs) with a higher affinity for the somatostatin subgroup 2 receptors SST2, SST3, and SST5 (IC50s = 0.5-1.8, 43-107, and 5.6-32 nM, respectively) than for the subgroup 1 receptors, SST1 and SST4 (IC50s = 500-2,330 and 66-2,100 nM, respectively).
- GC43888 Icatibant (acetate) Icatibant (Acetat) (HOE-140-Acetat) ist ein potenter und spezifischer Peptidantagonist des Bradykinin-B2-Rezeptors mit einem IC50- und Ki-Wert von 1,07 nM bzw. 0,798 nM.
- GC43846 Histone H3K27Me1 (23-34) (trifluoroacetate salt) Histone H3K27Me1 (23-34) is a peptide fragment of histone H3 that corresponds to amino acid residues 24-35 of the human histone H3.1 and H3.2 sequences.
- GC43832 Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt) Histone H3 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.3 sequence and is biotinylated via a C-terminal GK linker.
- GC43831 Histone H3 (21-44)-GK-biotin (trifluoroacetate salt) Histone H3 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.1 and 3.2 sequences and is biotinylated via a C-terminal GK linker.
- GC43785 GRP (porcine) (trifluoroacetate salt) Gastrin-releasing peptide (GRP) is a neuropeptide that stimulates gastrin release.
- GC43784 GRP (human) (trifluoroacetate salt) Gastrin-releasing peptide (GRP) is a neuropeptide that stimulates gastrin release.
- GC43754 Ghrelin (rat) (trifluoroacetate salt) Ghrelin is an endogenous gastrointestinal hormone and neuropeptide that binds to the growth hormone (GH) secretagogue receptor (GHS-R).
- GC43751 GHK GHK ist ein Tripeptid, das aus Glycin-, L-Histidin- und L-Lysin-Resten besteht, die der Reihe nach verbunden sind.
- GC43659 Feglymycin Feglymycin is a 13-amino acid peptide originally isolated from Streptomyces that has antibacterial and antiviral activities.
- GC43645 Extracellular Death Factor Programmed cell death in bacteria is dependent on a system of cell-to-cell communication termed quorum sensing.
- GC43608 Endothelin-3 (human, rat) (trifluoroacetate salt) Endothelin-3 is a peptide vasoconstricter and a ligand of the endothelin (ET) receptors ETA and ETB (Kbs = 1.05 and 1.49, respectively).
- GC43398 Defensin HNP-3 (human) (trifluoroacetate salt) Defensin HNP-3 is a peptide secreted by human polymorphonuclear leukocytes (PMNs) that has antimicrobial properties.
- GC43220 Cdk5 Substrate Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is predominantly active in neuronal tissues.
- GC43215 CCK Octapeptide (non-sulfated), (trifluoroacetate salt) Cholecystokinin (CCK) octapeptide is a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety.
- GC43214 CCK (26-31) (non-sulfated) CCK (26-31) is an N-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety.
- GC43213 CCK (26-30) (sulfated) CCK (26-30) is an N-terminal fragment of CCK, a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety.
- GC43145 Casein Kinase 2 Substrate (trifluoroacetate salt) Casein kinase 2 substrate is a peptide substrate for casein kinase 2 (CK2).
- GC43129 CALP1 (trifluoroacetate salt) CALP1 is an 8-residue calcium-like peptide that interacts with an EF hand motif based on the troponin C superfamily calcium binding site.
- GC43127 Calcitonin (salmon) (trifluoroacetate salt) Calcitonin is a peptide hormone that lowers blood calcium level and inhibits bone resorption.
- GC42973 Brain-Derived Basic Fibroblast Growth Factor (1-24) (bovine) (trifluoroacetate salt) Brain-derived basic fibroblast growth factor (1-24) (brain-derived bFGF) is a peptide fragment of brain-derived bFGF.
- GC42972 Brain-Derived Acidic Fibroblast Growth Factor (1-11) (bovine) (trifluoroacetate salt) Brain-derived acidic fibroblast growth factor (brain-derived aFGF) (1-11) is a peptide fragment of brain-derived aFGF.
- GC42971 Brain-Derived Acidic Fibroblast Growth Factor (102-111) (bovine) (trifluoroacetate salt) Brain-derived acidic fibroblast growth factor (102-111) is a peptide fragment of brain-derived acidic fibroblast growth factor (aFGF).
- GC42936 Biotin Tripeptide-1 Biotin tripeptide-1 is an extracellular matrix (ECM) peptide that has been conjugated to biotin.
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GC42809
Angiotensin II (3-8) (human, rat, mouse) (trifluoroacetate salt)
Angiotensin II (3-8) is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II.
- GC42808 Angiotensin I (human, rat, mouse) (trifluoroacetate salt) Angiotensin I is an endogenous peptide that is converted to the vasoconstrictor angiotensin II by angiotensin-converting enzyme (ACE).
- GC42796 Amylin (human) (trifluoroacetate salt) Amylin is a 37-residue peptide hormone secreted from pancreatic β-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety.
- GC42701 Acetyl Tetrapeptide-3 Acetyl tetrapeptide-3 is a biomimetic peptide.
- GC34684 Neurokinin B TFA Neurokinin B TFA gehÖrt zur Familie der Tachykinine von Peptiden.
- GC33788 Adrenocorticotropic Hormone (ACTH) (18-39), human (CLIP (human)) Adrenocorticotropes Hormon (ACTH) (18-39), human (CLIP (human)) ist ein Corticotropin-Ähnliches Zwischenlappen-Peptid, das in den Melanotrophen des Zwischenlappens der Hypophyse produziert wird.
- GC33680 Phe-Met-Arg-Phe amide trifluoroacetate Phe-Met-Arg-Phe-Amidtrifluoracetat ist ein Aktivator des K+-Stroms mit einer ED50 von 23 nM in den peptidergen kaudodorsalen Neuronen.
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GC33595
β-CGRP, human (Human β-CGRP)
β-CGRP, menschlich (Human β-CGRP) ist eines der Calcitonin-Peptide und wirkt über den Komplex aus dem calcitonin-receptor-like receptor (CRLR) und dem receptor-activity-modifying protein (RAMP), mit IC50-Werten von 1 nM und 300 nM für CRLR/RAMP1 bzw. CRLR/RAMP2 in Zellen.
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GC33369
Polymyxin B nonapeptide
Polymyxin B Nonapeptid, als kationisches zyklisches Peptid, das aus Polymyxin B abgeleitet ist, kann wahrscheinlich die Permeabilität der äußeren Membran (OM) von GNB gegenüber hydrophoben Antibiotika erhöhen.
- GC32772 Triptorelin ([DTrp6]-LH-RH) A synthetic GNRH peptide agonist
- GC32615 Adrenomedullin (AM) (22-52), human (22-52-Adrenomedullin (human)) Adrenomedullin (AM) (22-52), human (22-52-Adrenomedullin (human)), ein NH2-terminal verkÜrztes Adrenomedullin-Analogon, ist ein Adrenomedullin-Rezeptor-Antagonist und antagonisiert auch den Calcitonin Generelated Peptide (CGRP)-Rezeptor im GefÄß der Hinterbeine Bett der Katze.
- GC32451 Examorelin (Hexarelin) A peptide agonist of GHS-R
- GC31530 ACTH 4-11 (Adrenocorticotropic Hormone (4-11), human) ACTH 4-11 (Adrenocorticotropes Hormon (4-11), human), ein Adrenocorticotropin-Hormonfragment, besitzt nur bei hohen Dosen (100 und 1000 nM) eine schwache ⋱-Melanozyten-stimulierendes Hormon (&7#945;-MSH).
- GC31360 Taspoglutide (ITM077) Taspoglutid (ITM077) ist ein langwirksamer Glucagon-like Peptide 1 (GLP-1)-Rezeptoragonist, der zur Behandlung von Typ-2-Diabetes entwickelt wurde und einen EC50-Wert von 0,06 nM hat.
- GC31184 Phe-Met-Arg-Phe, amide Phe-Met-Arg-Phe, Amid, dosisabhÄngig (ED50=23 nM) aktiviert einen K+-Strom in den peptidergen kaudodorsalen Neuronen.
- GC30291 Calcitonin, eel (Thyrocalcitonin eel) Calcitonin, Aal (Thyrocalcitonin Aal) ist das SchilddrÜsenhormonpeptid, das zur Regulierung der KalziumhomÖostase beitrÄgt und in der Erforschung der postmenopausalen Osteoporose weit verbreitet ist.
- GC30108 Thymalfasin (Thymosin α1) Thymalfasin (Thymosin α1) ist ein immunmodulierendes Mittel, das die Thl-Immunantwort verstÄrken kann.
- GC18553 CCK (26-31) (sulfated) CCK (26-31) is an N-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety.
- GC18384 CCK (27-33) (non-sulfated) CCK (27-33) is a C-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety.
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GC18218
MMP-3 Inhibitor
MMP-3 inhibitor is a peptide inhibitor of matrix metalloproteinase-3 (MMP-3) with a Ki value of 95 nM.
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GC10284
Apelin-13
Apelin-13 ist ein Peptid, das als Ligand des G-Protein-gekoppelten Rezeptors APJ bekannt ist.
- GC10569 Nisin A Nisin A ist ein Bacteriocin, das von einer Gruppe grampositiver Bakterien produziert wird, die zu den Arten Lactococcus und Streptococcus gehÖrt.
- GC15319 Cyclosporin H Cyclosporin H ist ein selektiver und wirksamer Inhibitor von FPR-1 (Formylpeptidrezeptor 1).
- GC10790 FSLLRY-NH2 FSLLRY-NH2 ist ein Inhibitor des Protease-aktivierten Rezeptors 2 (PAR2).
- GC12366 LPYFD-NH2 LPYFD-NH2, ein Pentapeptid, Übt eine gewisse Hemmwirkung auf die Aggregation von Aβ(1-42) aus.
- GC13077 RETF-4NA RETF-4NA, ein Chymase-spezifisches Substrat, ist ein empfindliches und selektives Substrat fÜr Chymase, wenn es frei oder an α2M gebunden ist.
- GC17133 Hemopressin (human, mouse) HÄmopressin ist ein Nonapeptid, das von der α1-Kette von HÄmoglobin abgeleitet ist und ursprÜnglich aus Rattenhirn-Homogenaten isoliert wurde.
- GC13806 Lys-γ3-MSH Lys-γ3-MSH ist ein Melanocortin-Peptid, das vom C-Terminus des Fragments von Pro-Opiomelanocortin (POMC) abgeleitet ist.