Cefapirin (Synonyms: Cefadyl,Cephapirin) |
Katalog-Nr.GC14253
One-Click Copy Product Info
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Cefapirin (Cefapirin) ist ein Ephalosporin-Antibiotikum mit antimikrobieller AktivitÄt mit breitem Spektrum.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 21593-23-7
Sample solution is provided at 25 µL, 10mM.
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Cefapirin is the first generation cephalosporin antibiotic. Cefapirin is broadly effective against gram-negative and gram-positive bacteria [1].
The antibacterial action of cefapirin was due to the inhibition of cell-wall synthesis, mediated by its binding to penicillin binding proteins. It was mainly used in veterinary medicine for intramammary treatment of mastitis and intrauterine treatment of endometritis in cattle [1,2].
Cefapirin was an antibiotic particularly suitable for the treatment of acute otitis media. In 210 strains isolated from the auricular exudate of childrens' acute otitis media, the MIC50 and MIC90 of cefapirin were 2 and 4 mg/l for 112 strains of Haemophilus. The MIC ranged from 0.25 to 4 mg/l for ten strains of Branhamella catarrhalis (9 secreted a beta-lactamase). Cefapirin had an extremely high activity with MIC50 and 90 less than 0.06 mg/l against Streptococcus pneumoniae. For the strains of Staphylococcus aureus sensitive to meticillin, one had a MIC less than 0.06 mg/l, and 11 had a MIC of 0.25 mg/l. For 14 strains of Enterobacteriaceae studied, the MIC 50 was 8 mg/l and the MIC 90 was 32 mg/l [3].
References:
[1] Committee for veterinary medicinal products: Cefapririn. EMEA, 1-6 (2001).
[2] Ray, P. ,Knowlton, K.F.,Shang, C., et al. Development and validation of a UPLC-MS/MS method to monitor cephapirin excretion in dairy cows following intramammary infusion. PLoS One 9(11), 1-12 (2014).
[3] Simonet M, Herrmann J L, Gehanno P, et al. Activity of cefapirin against bacterial strains isolated from acute otitis media in children[J]. Pathologie-biologie, 1990, 38(5): 352-354.
| Cas No. | 21593-23-7 | SDF | |
| Überlieferungen | Cefadyl,Cephapirin | ||
| Chemical Name | (6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | ||
| Canonical SMILES | O=C(N[C@@H]1C(N2[C@]1([H])SCC(COC(C)=O)=C2C(O)=O)=O)CSC3=CC=NC=C3 | ||
| Formula | C17H17N3O6S2 | M.Wt | 423.5 |
| Löslichkeit | ≤10mg/ml in DMSO;5mg/ml in dimethyl formamide | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.3613 mL | 11.8064 mL | 23.6128 mL |
| 5 mM | 472.3 μL | 2.3613 mL | 4.7226 mL |
| 10 mM | 236.1 μL | 1.1806 mL | 2.3613 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)