Chrysoeriol (Synonyms: 3'-methoxy Apigenin, Luteolin 3'-methyl ether) |
Katalog-Nr.GC60109
One-Click Copy Product Info
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Chrysoeriol, ein natÜrliches Flavonoid, das aus der tropischen Pflanze Coronopus didymus extrahiert wird, weist eine starke antioxidative Wirkung auf.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 491-71-4
Sample solution is provided at 25 µL, 10mM.
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Chrysoeriol is a natural flavonoid found in Coronopus didymus that exerts anti-inflammatory effects by inhibiting the JAK2/STAT3 and NF-κB signaling pathways[1,2]. Chrysoeriol possesses potent antioxidant, anti-inflammatory, and anticancer activities and is commonly used in the treatment and research of acute skin inflammation, diabetes, and cardiovascular diseases[3,4].
In vitro, SH-SY5Y cells were pretreated with Chrysoeriol (5, 10, and 20μM) for 4h, followed by co-incubation with 1mM 1-methyl-4-phenylpyridinium iodide (MPP+) for an additional 24h. Chrysoeriol dose-dependently attenuated MPP+-induced cell death, with 20μM Chrysoeriol significantly increasing cell survival from 50% to approximately 90%[5]. ARPE-19 cells were pretreated with Chrysoeriol (2.5 and 5μM) for 2h, followed by co-incubation with H2O2 (500μM) for an additional 24h. Chrysoeriol pretreatment significantly upregulated the mRNA expression of the mitochondrial transcription factor TFAM and the DNA polymerase subunit gamma-1 (POLG)[6].
In vivo, Chrysoeriol (20mg/kg) was orally administered to streptozotocin (STZ)-induced diabetic rats for 45 days, which significantly reduced the elevated serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), bringing them back to near-normal levels[7].
References:
[1] PRABHAKAR K R, SRINIVASAN K K, RAO P G M. Chemical investigation, anti-inflammatory and wound healing properties of Coronopus didymus[J]. Pharmaceutical Biology, 2002, 40(7): 490-493.
[2] WU J Y, CHEN Y J, BAI L, et al. Chrysoeriol ameliorates TPA-induced acute skin inflammation in mice and inhibits NF-κB and STAT3 pathways[J]. Phytomedicine, 2020, 68: 153173.
[3] ABOULAGHRAS S, SAHIB N, BAKRIM S, et al. Health benefits and pharmacological aspects of chrysoeriol[J]. Pharmaceuticals, 2022, 15(8): 973.
[4] CHA B Y, SHI W L, YONEZAWA T, et al. An inhibitory effect of chrysoeriol on platelet-derived growth factor (PDGF)-induced proliferation and PDGF receptor signaling in human aortic smooth muscle cells[J]. Journal of Pharmacological Sciences, 2009, 110(1): 105-110.
[5] LIMBOONREUNG T, TUCHINDA P, CHONGTHAMMAKUN S. Chrysoeriol mediates mitochondrial protection via PI3K/Akt pathway in MPP⁺ treated SH-SY5Y cells[J]. Neuroscience Letters, 2020, 714: 134545.
[6] KIM M H, KWON S Y, WOO S Y, et al. Antioxidative effects of chrysoeriol via activation of the Nrf2 signaling pathway and modulation of mitochondrial function[J]. Molecules, 2021, 26(2): 313.
[7] KRISHNAN B, PUGALENDI K V, SARAVANAN R. Ameliorative potential of Chrysoeriol, a bioactive flavonoid on oxidative stress and hepatic marker enzymes in STZ induced diabetic rats[J]. Asian Journal of Pharmacy and Pharmacology, 2019, 5(3): 614-624.
| Cell experiment [1]: | |
Cell lines | SH-SY5Y cells |
Preparation Method | SH-SY5Y cells were pre-treated with different doses of Chrysoeriol for 4h followed by 1mM MPP+ for 24h, and then subjected to MTT assay for cell viability measurement. |
Reaction Conditions | 5, 10, and 20μM; 4h |
Applications | MPP+-reduced cell viability was partially but significantly attenuated by the treatment of cells with Chrysoeriol in a concentration-dependent manner. Chrysoeriol at the concentration of 20µM significantly reduced the MPP+-induced cell death, and improved the percentage of survival cells from 50% to 90%. |
| Animal experiment [2]: | |
Animal models | STZ-induced diabetic rats |
Preparation Method | STZ-induced diabetic rats (plasma glucose > 255mg/dl) were orally administered Chrysoeriol (20mg/kg) for 45 days, then serum ALT and AST levels were measured using the Reitman and Frankel method. |
Dosage form | 20mg/kg; 45 days; p.o. |
Applications | Treatment with Chrysoeriol significantly reduced elevated ALT and AST levels in serum, restoring them to near-normal levels. |
References: | |
| Cas No. | 491-71-4 | SDF | |
| Überlieferungen | 3'-methoxy Apigenin, Luteolin 3'-methyl ether | ||
| Canonical SMILES | O=C1C=C(C2=CC=C(O)C(OC)=C2)OC3=CC(O)=CC(O)=C13 | ||
| Formula | C16H12O6 | M.Wt | 300.26 |
| Löslichkeit | DMSO : 100 mg/mL (333.04 mM; Need ultrasonic) | Storage | Store at 2-8°C,protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.3304 mL | 16.6522 mL | 33.3045 mL |
| 5 mM | 666.1 μL | 3.3304 mL | 6.6609 mL |
| 10 mM | 333 μL | 1.6652 mL | 3.3304 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)