DC1-SMe |
| Katalog-Nr.GC34190 |
DC1Sme, ein DC1-Derivat, zeigt IC50-Werte von 22 pM, 10 pM, 32 pM und 250 pM für Ramos-, Namalwa-, HL60/s- bzw. COLO 205-Krebszellen. DC1, ein Analogon des an die kleine Furche bindenden DNA-Alkylators CC-1065, ist ein ADC-Cytotoxin. DC1 kann bei der Synthese von Antikörper-Wirkstoff-Konjugaten zur gezielten Behandlung von Krebs verwendet werden.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 501666-85-9
Sample solution is provided at 25 µL, 10mM.
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DC1-Sme is an antibody conjugate of phosphate prodrug of cytotoxic DNA alkylators for the targeted treatment of cancer.
[1]. Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82.
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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