Eicosatetraynoic Acid (Synonyms: ETYA) |
Katalog-Nr.GC12229
One-Click Copy Product Info
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EicosatetraynsÄure (ETYA) ist ein unspezifischer Inhibitor von Cyclooxygenase und Lipoxygenase (ID50 = 8 μM bzw. 4 μM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1191-85-1
Sample solution is provided at 25 µL, 10mM.
Eicosatetraynoic Acid is nonspecific inhibitor of cyclooxygenases and lipoxygenases [1].
Cyclooxygenase (COX) is the key enzyme required for the conversion of arachidonic acid to prostaglandins. Two cyclooxygenase isoforms have been identified: COX-1 and COX-2. The COX-1 enzyme is produced constitutively (i.e., gastric mucosa) and COX-2 is inducible (i.e., sites of inflammation). Cyclooxygenase has been involved in different physiological situations and disease processes ranging from inflammation to cancer [2]. Lipoxygenases belong to a family of non-heme and iron-containing enzymes and serve diverse roles as autocrine signals that regulate the function of their parent cells, paracrine signals that regulate the function of nearby cells, and endocrine signals that regulate the function of distant cells [3].
In human platelet, Eicosatetraynoic acid inhibited 12-LO and COX-1 with IC50 values of 4 μM and 8 μM, respectively [1]. Eicosatetraynoic acid acted as a PPAR ligand which activated PPARα and PPARγ chimeras at concentrations of 10 μM [4].
References:
[1] Hammarstrm S. Selective inhibition of platelet n—8 lipoxygenase by 5, 8, 11-eicosatriynoic acid[J]. Biochimica et Biophysica Acta (BBA)-Lipids and Lipid Metabolism, 1977, 487(3): 517-519.
[2] Dubois R N, Abramson S B, Crofford L, et al. Cyclooxygenase in biology and disease[J]. The FASEB journal, 1998, 12(12): 1063-1073.
[3] Feussner I, Wasternack C. The lipoxygenase pathway[J]. Annual review of plant biology, 2002, 53(1): 275-297.
[4] Kliewer S A, Lenhard J M, Willson T M, et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation[J]. Cell, 1995, 83(5): 813-819.
| Cas No. | 1191-85-1 | SDF | |
| Überlieferungen | ETYA | ||
| Chemical Name | 5,8,11,14-eicosatetraynoic acid | ||
| Canonical SMILES | CCCCCCCCCCCCCCCCCCCC(=O)O | ||
| Formula | C20H24O2 | M.Wt | 296.4 |
| Löslichkeit | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 1 mg/ml | Storage | Store at -20°C,unstable in solution, ready to use. |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.3738 mL | 16.8691 mL | 33.7382 mL |
| 5 mM | 674.8 μL | 3.3738 mL | 6.7476 mL |
| 10 mM | 337.4 μL | 1.6869 mL | 3.3738 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)