ETP 45658 |
| Katalog-Nr.GC50072 |
ETP 45658 ist ein potenter PI3K-Inhibitor mit IC50-Werten von 22,0 nM, 39,8 nM, 129,0 nM und 717,3 nM für PI3Kα, PI3Kδ, PI3Kβ bzw. PI3Kγ. ETP 45658 kann auch DNA-PK (IC50\u003d70,6 nM) und mTOR (IC50\u003d152,0 nM) hemmen. ETP 45658 kann für die Krebsforschung verwendet werden.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1198357-79-7
Sample solution is provided at 25 µL, 10mM.
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PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively). Also inhibits DNA-PK and mTOR (IC50 values are 70.6 and 152 nM respectively). Inhibits proliferation of multiple cancer cell lines in vitro and reduces Akt phosphorylation levels in vivo.
Link et al (2009) Chemical interrogation of FOXO3a nuclear translocation identifies potent and selective inhibitors of phosphoinositide 3-kinases. J.Biol.Chem. 284 28392 PMID:19690175 |Hill et al (2014) A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes. Breast Cancer Res. 16 482 PMID:25488803
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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