8-Hydroxyguanine |
| Katalog-Nr.GC35204 |
8-Hydroxyguanin ist eine bedeutende prÄmutagene LÄsion, die von reaktiven Sauerstoffspezies erzeugt wird.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 5614-64-2
Sample solution is provided at 25 µL, 10mM.
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8-Hydroxyguanine is a major pre-mutagenic lesion generated from reactive oxygen species. It causes G-T and A-C substitutions. Human Endogenous Metabolite
[1]. Arai T, et al. High accumulation of oxidative DNA damage, 8-hydroxyguanine, in Mmh/Ogg1 deficient mice by chronic oxidative stress. Carcinogenesis. 2002 Dec;23(12):2005-10. [2]. Floyd RA, et al. The role of 8-hydroxyguanine in carcinogenesis. Carcinogenesis. 1990 Sep;11(9):1447-50. [3]. Cheng KC, et al. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions. J Biol Chem. 1992 Jan 5;267(1):166-72.
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