ACX-362E (Synonyms: ACX-362E; GLS-362E) |
| Katalog-Nr.GC35247 |
ACX-362E (ACX-362E) ist ein erster oral aktiver DNA-Polymerase IIIC (pol IIIC)-Inhibitor seiner Klasse mit einem Ki von 0,325 μM fÜr die DNA pol IIIC von C.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1275582-97-2
Sample solution is provided at 25 µL, 10mM.
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ACX-362E is an orally available DNA polymerase IIIC (pol IIIC) inhibitor, acts as an antimicrobial agent to treat Gram-positive infections, with a MIC50 of 2 μg/mL for C. difficile. ACX-362E displays very potent in vitro and in vivo activities against broad spectrum of C. difficile pathogens[1]. MIC50: 2 μg/mL (C. difficile)[1]
[1]. Xu WC, et al. Discovery and development of DNA polymerase IIIC inhibitors to treat Gram-positive infections. Bioorg Med Chem. 2019 Jun 11. pii: S0968-0896(19)30663-7.
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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