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Aristolactam I

Katalog-Nr.GC35388

Aristololactam I (AL-I), ist der Hauptmetabolit von AristolochinsÄure I (AA-I), ist an den Prozessen beteiligt, die zu NierenschÄden fÜhren.

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Aristolactam I Chemische Struktur

Cas No.: 13395-02-3

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Aristololactam I (AL-I), is the main metabolite of aristolochic acid I (AA-I), participates in the processes that lead to renal damage.Aristololactam I (AL-I) directly injures renal proximal tubule cells, the cytotoxic potency of AL-I is higher than that of AA-I and that the cytotoxic effects of these molecules are mediated through the induction of apoptosis in a caspase-3-dependent pathway[1].

[1]. Li J, et al. Toxicities of aristolochic acid I and aristololactam I in cultured renal epithelial cells. Toxicol In Vitro. 2010 Jun;24(4):1092-7.

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