BPR1K871 (Synonyms: DBPR114) |
| Katalog-Nr.GC35545 |
BPR1K871 ist ein potenter und selektiver dualer FLT3/AURKA-Inhibitor mit IC50-Werten von 19 nM und 22 nM fÜr FLT3 bzw. AURKA und fungiert als prÄklinischer Entwicklungskandidat fÜr die Krebstherapie.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2443767-35-7
Sample solution is provided at 25 µL, 10mM.
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BPR1K871 is a potent and selective dual FLT3/AURKA inhibitor with IC50s of 19 nM and 22 nM for FLT3 and AURKA, respectively, acts as a preclinical development candidate for anti-cancer therapy[1]. IC50: 19 nM (FLT3), 22 nM (AURKA)[1]
BPR1K871 shows potent anti-proliferative activities in MOLM-13 and MV4-11 AML cells with an EC50 of ~ 5 nM[1].
BPR1K871 is a multi-kinase inhibitor for the treatment of acute myeloid leukemia (AML) and solid tumors[1].
[1]. Hsu YC, et al. Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation. 2016 Dec 27; 7(52): 86239-86256.
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)
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